919085-47-5

Upstream product

• 23275-42-5 N-Cyan-(3-nitro-benzamidin) 
• 3724-43-4 Vilsmeier reagent 
• 619-24-9 3-nitrobenzonitrile 

Downstream Products

• 919085-48-6 C₁₆H₁₃N₅O₃ 
• 919085-51-1 C₂₄H₃₀N₆O₃ 
• 919085-50-0 C₂₃H₂₈N₆O₃ 
• 919085-49-7 C₁₆H₁₅N₅O 

Relevant academic research and scientific papers

CYCLIC ANILINOPYRIDINOTRIAZINES AS GSK-3 INHIBITORS

The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N; —X1— represents C1-4alkyl, in particular methyl; —X2— represents —C1-4alkyl- or —C1-4alkyl-NR7—, in particular propyl, -ethyl-NR7— or -propyl-NR7—; —Y— represents —NR2—C1-6alkyl-CO—NR4—, -Het1-C1-6alkyl-CO—NR5— or -Het2-CO—NR6— and wherein the —C1-6alkyl-linker of —NR2—C1-6alkyl-CO—NR4— or -Het1-C1-6alkyl-CO—NR5— is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl; R1 represents hydrogen, chloro, fluoro or bromo; R2 represents —C1-4alkyl-, in particular ethyl or methyl; R7 represents hydrogen; R8 represents hydrogen; R4, R5 and R6 represent hydrogen; Het1 is selected from piperazinyl or piperidinyl, in particular -piperazinyl; Het2 selected from pyrrolidinyl or piperidinyl, in particular pyrrolidinyl wherein said pyrrolidinyl is optionally substituted with hydroxy.