919092-47-0Relevant academic research and scientific papers
NOVEL CHALCONE DERIVATIVES WHICH INHIBIT THE IL-5 ACTIVITY
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Page/Page column 6, (2008/06/13)
Disclosed herein are novel chalcone derivatives, which are low-molecular nonpeptide substances as interleukin-5 (IL-5) inhibitors having the effect of treating chronic allergic diseases, as well as a preparation method thereof and the use thereof as IL-5
Structural requirement of chalcones for the inhibitory activity of interleukin-5
Yang, Hyun-Mo,Shin, Hye-Rim,Cho, Soo-Hyun,Bang, Seong-Cheol,Song, Gyu-Yong,Ju, Jung-Hun,Kim, Mi-Kyeong,Lee, Seung-Ho,Ryu, Jae-Chun,Kim, Youngsoo,Jung, Sang-Hun
, p. 104 - 111 (2007/10/03)
Novel chalcones were found as potent inhibitors of interleukin (IL)-5. 1-(2-Benzyloxy-6-hydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one (2b, 78.8% inhibition at 50 μM, IC50 = 25.3 μM) was initially identified as a potent inhibitor of IL-5. Th
