91929-46-3Relevant academic research and scientific papers
Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings
Ito, Nobuhiro,Esaki, Hiroyoshi,Maesawa, Tsuneaki,Imamiya, Eikoh,Maegawa, Tomohiro,Sajiki, Hironao
experimental part, p. 278 - 286 (2009/03/12)
An effective and applicable deuteration method for aromatic rings using Pt/C-D2O-H2 system was established. Especially, phenol was fully deuterated even at room temperature, and other electron-rich aromatic nuclei were efficiently deuterated under mild conditions. The scope and limitations of the presence method and its application to the synthesis of deuterium-labeled biologically active compounds and deuterium-labeled building blocks for practical multi-gram scale syntheses are reported. 2008 The Chemical Society of Japan.
Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C
Sajiki, Hironao,Ito, Nobuhiro,Esaki, Hiroyoshi,Maesawa, Tsuneaki,Maegawa, Tomohiro,Hirota, Kosaku
, p. 6995 - 6998 (2007/10/03)
An effective and applicable Pt/C-catalyzed deuteration method of aromatic rings using D2O as a deuterium source under hydrogen atmosphere was developed. Five percent Pt/C would lead to quite effective H-D exchange results on the aromatic ring systems. The reaction is general for a variety of aromatic compounds including biologically active compounds.
