919298-83-2

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 919298-77-4 1,3-bis(tert-butyldimethylsilyloxy)-5-iodo-2,4-dimethyl-pentane 
• 443761-71-5 (2R,3S,4S)-3,5-bis(tert-butyldimethylsilyloxy)-2,4-dimethylpentan-1-ol 
• 443761-81-7 (2R,3S,4S)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentanal 
• 457623-10-8 4R,6-bis(tert-butyldimethylsilanyloxy)-3S,5S-dimethylhex-1-ene 
• 184528-64-1 (2S,3S)-3,4-(di(tert-butyldimethylsilyloxy))-2-methyl-butanal 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 106296-58-6 (2S,3R,4S)-1-(tert-butyldimethylsilyloxy)-2,4-dimethylhex-5-en-3-ol 
• 919298-82-1 C₅₁H₉₂O₆Si₃ 
• 919298-94-5 5,11,13-tris-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,4,8,10,12-pentamethyl-tridecan-1-ol 
• 919298-93-4 2-(4-methoxy-phenyl)-5-methyl-4-[2,8,10-tris-(tert-butyl-dimethyl-silanyloxy)-1,5,7,9-tetramethyl-decyl]-[1,3]dioxane 
• 919298-92-3 5,11,13-tris-(tert-butyl-dimethyl-silanyloxy)-2,4,8,10,12-pentamethyl-tridecane-1,3-diol 
• 919298-81-0 C₃₅H₆₀O₅Si₂ 
• 919298-74-1 2-[5,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethyl-heptane-1-sulfonyl]benzothiazole 

Downstream Products

• 919298-99-0 7,9,13,19-tetrakis-(tert-butyl-dimethyl-silanyloxy)-21-(4-methoxy-benzyloxy)-6,12,14,16,20,22-hexamethyl-hexacosa-2,4,10,23,25-pentaenoic acid ethyl ester 
• 919298-85-4 (2Z,4E,6R,7S,9S,10Z,12S,13R,14S,16S,19R,21S,22S,23Z)-9-hydroxy-21-(4-methoxy-benzyloxy)-7,13,19-tris(tert-butyldimethylsilyloxy)-6,12,14,16,20,22-hexamethyl-hexaeicosa-2,4,10,23,25-pentaenoic acid ethyl ester 
• 919298-84-3 (5R,6S,8S,11R)-5-((S,Z)-4-iodobut-3-en-2-yl)-11-((2R,3S,4S,Z)-3-(4-methoxybenzyloxy)-4-methylocta-5,7-dien-2-yl)-2,2,3,3,6,8,13,13,14,14-decamethyl-4,12-dioxa-3,13-disilapentadecane 
• 919298-97-8 (-)-(Z)-(2R,3R,4S,6S,9R,10R,11S,12S)-3,9-bis-(tert-butyldimethylsilanyloxy)-11-(4-methoxybenzyloxy)-2,4,6,10,12-pentamethylhexadeca-13,15-dienal 
• 919298-96-7 (+)-(Z)-(2S,3R,4S,6S,9R,10R,11S,12S)-3,9-bis-(tert-butyldimethylsilanyloxy)-11-(4-methoxybenzyloxy)-2,4,6,10,12-pentamethylhexadeca-13,15-dien-1-ol 

Relevant academic research and scientific papers

Probing o-diphenylphosphanyl benzoate (o-DPPB)-directed C - C bond formation: Total synthesis of dictyostatin

Herein, we report a robust total synthesis of dictyostatin. This polyketide natural product has attracted much attention because of its impressive antiproliferative activity against several human cancer-cell lines. We accomplished its synthesis in a highly convergent manner from three fragments of equal complexity, which were prepared on multigram scale. The southern and northwestern subunits were constructed through application of our o-DPPB-directed hydroformylation and allylic substitution methodology, respectively. These methods generated the C6 and C14 stereocenters of dictyostatin with good diastereoselectivities and simultaneously allowed further elaboration of the fragments by Wittig olefination and Sharpless asymmetric epoxidation, respectively. The compelling performance of the hydroformylation and allylic substitution with regard to practicability, selectivity, and scale underline their value for the construction of propionate motifs.

Total synthesis of potential antitumor agent, (-)-dictyostatin

(Chemical Equation Presented) The potential antitumor agent (-)-dictyostatin has been synthesized utilizing Brown crotylboration to achieve eight of the eleven chiral centers. The yield for the 26-step longest sequence is ～4%. The C9-C10 coupling is achie