91933-40-3Relevant academic research and scientific papers
Binding of a homologous series of anthraquinones to DNA
McKnight, Ruel E.,Zhang, Jianguo,Dixon, Dabney W.
, p. 401 - 404 (2004)
The DNA binding characteristics of a series of homologous 2, 6-disubstituted anthraquinone threading intercalators bearing one to four ethylene glycol units in their side chains have been studied. Binding constants were measured via surface plasmon resonance (SPR). These compounds bind to an AT-rich hairpin with slightly higher affinity than to a GC-rich hairpin. The binding constants decrease as the length of the side chain increases.
Competitive intramolecular hydrogen bonding in oligo(ethylene oxide) substituted quadruple hydrogen bonded systems
De Greef, Tom F.A.,Nieuwenhuizen, Marko M.L.,Sijbesma, Rint P.,Meijer
supporting information; experimental part, p. 598 - 610 (2010/04/26)
(Figure Presented) A series of oligo(ethylene oxide) (oligoEO) substituted 2-ureido-pyrimidinones (UPy), differing in the number of ethylene oxide units and the length of the aliphatic spacer connecting the oligoEO side chain with the UPy group, have been prepared. It was found that variation in these structural parameters strongly influences the dimerization constant (K dim) of theUPy dimer and the association constant (Ka) of UPy with 2,7-diamido-1,8-naphthyridine (NaPy) in chloroform. By analyzing the relation between dimerization strength, length of aliphatic spacer, and the number of EO units in the oligoEO chain, we present strong evidence that the reduction in hydrogen bond strength is caused by competitive intramolecular hydrogen bonding of the ether atoms of the oligoEO chain to the hydrogen bond donors of the UPy unit.
