3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE, also known as Zatebradine Hydrochloride, is a pharmaceutical compound with specific cardiovascular properties. It is characterized by its ability to exhibit bradycardic effects and to block the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE is a sinus node inhibitor, which makes it a potential candidate for the treatment of certain cardiovascular conditions.
91940-87-3
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Basic information
- Product Name: 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
- Synonyms: 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE;UL-FS49;ZATEBRADINE HYDROCHLORIDE;UL-FS49, 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride;2H-3-Benzazepin-2-one, 3-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride;Zatebradine HCl;ULFS 49CL;Zatebradine dihydrochloride
- CAS NO:91940-87-3
- Molecular Formula: C26H36N2O5*ClH
- Molecular Weight: 493.04
- EINECS: N/A
- Product Categories: Ion transporter and other ion channel
- Mol File: 91940-87-3.mol
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Chemical Properties
- Melting Point: 188° and mp 168°
- Boiling Point: 612.5°Cat760mmHg
- Flash Point: 324.3°C
- Appearance: white/solid
- Density: 1.115g/cm3
- Vapor Pressure: 6.09E-15mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: H2O: ~14 mg/mL
- CAS DataBase Reference: 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE(CAS DataBase Reference)
- NIST Chemistry Reference: 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE(91940-87-3)
- EPA Substance Registry System: 3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE(91940-87-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 91940-87-3(Hazardous Substances Data)
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91940-87-3 Usage
Uses
Used in Pharmaceutical Industry:Zatebradine Hydrochloride is used as a sinus node inhibitor for the treatment of conditions that require heart rate reduction, such as tachycardia. Its ability to block the HCN channels helps in managing the heart's electrical activity and maintaining a stable heart rate.
Used in Cardiology:
In the field of cardiology, Zatebradine Hydrochloride is utilized for its bradycardic properties, which can be beneficial in the management of patients with abnormally high heart rates. By slowing down the heart rate, it can help alleviate symptoms and improve the overall cardiovascular health of the patients.
Biological Activity
Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current (I f ) in sinoatrial node cells (EC 50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC 50 of 13.4 μ M).Biochem/physiol Actions
Zatebradine is a bradycardiac agent.Check Digit Verification of cas no
The CAS Registry Mumber 91940-87-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,9,4 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.Calculate Digit Verification of CAS Registry Number 91940-87:
(7*9)+(6*1)+(5*9)+(4*4)+(3*0)+(2*8)+(1*7)=153
153 % 10 = 3
So 91940-87-3 is a valid CAS Registry Number.
InChI:InChI=1/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
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3-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-1,3,4,5-TETRAHYDRO-7,8-DIMETHOXY-2H-3-BENZAZEPIN-2-ONE HYDROCHLORIDE
