91945-01-6

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 767-00-0 4-cyanophenol 

Downstream Products

• 103278-74-6 3,4-bis-[5-(4-cyano-phenoxy)-pentyloxy]-benzonitrile 
• 91945-00-5 4-[6-(3-Methyl-isoxazol-5-yl)-hexyloxy]-benzonitrile 
• 84223-62-1 4-<5-(4-Thiocarbamoylphenoxy)pentyloxy>benzonitril 
• 164029-23-6 1-Piperidino-5-(4-cyanophenoxy)pentane 
• 50381-86-7 3-bromo-4,4'-pentanediyldioxy-di-benzonitrile 
• 664376-75-4 4-{[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl]oxy}benzonitrile 
• 854895-31-1 2-(4-(5-(4-cyanophenoxy)pentyloxy)phenyl)benzofuran-5-carbonitrile 
• 1190367-94-2 1-(p-cyanophenoxypentyl)-7-azaindole 
• 1190367-95-3 p-amidophenoxypentylbromide 
• 1445849-45-5 1-[5-(4-cyanophenoxy)pentyl]uracil 
• 144860-40-2 3-iodo-4,4'-pentanediyldioxy-bis-benzamidine 
• 1313240-70-8 5-(4-cyanophenoxy)pentyl methacrylate 
• 854895-39-9 2-(4-(5-(4-cyanophenoxy)pentyloxy)phenyl)benzofuran-6-carbonitrile 
• 854895-35-5 2-(3-(5-(4-cyanophenoxy)pentyloxy)phenyl)benzofuran-6-carbonitrile 

Relevant academic research and scientific papers

ANALOGUES OF PENTAMIDINE AND USES THEREFOR

The present disclosure provides a group of aromatic (e.g., pyridinyl, pyrimidinyl, pyrazinyl, or phenyl) diamidine analogs and pharmaceutically acceptable salts that are useful for treating a proliferative disease. The proliferative disease may include solid cancer or blood cancer. Compositions, methods of synthesizing the same and methods for treating various cancer using the analogs are disclosed herein. The present disclosure also provides pharmaceutical formulations comprising at least one of the compounds with a pharmaceutically acceptable carrier, diluent or excipient therefor.

gem-Dithioacetylated indole derivatives as novel antileishmanial agents

In this communication we report a serendipitously discovered hybrid molecule 1, combining fragment of 3 (an in vivo active antileishmanial molecule) with H2S donor moiety (known for bimodal behavior of cytoprotection and apoptosis), as antileis

Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides

The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.

Liquid crystalline dihydroazulene photoswitches

A large selection of photochromic dihydroazulene (DHA) molecules incorporating various substituents at position 2 of the DHA core was prepared and investigated for their ability to form liquid crystalline phases. Incorporation of an octyloxy-substituted b

Fast synthesis employing a microwave assisted neat protocol of new monomers potentially useful for the preparation of PDLC films

It has been repor ted that the length of the molecular chain and the rigidity of molecules influence the structure of the polymer network in PDLC films and hence the electro-optical proper ties of the composites. Herein, a series of new aromatic monomeric monomethacrylates, bismethacrylates and monovinylbenzene derivatives with a mesogenic core were successfully synthesized under microwave irradiation. The microwave assisted synthesis resulted in decreased reaction times, reduced solvent requirement, increased operational simplicity, and in most cases, improved yields and selectivity. Versita Sp. z o.o.

Films based on new methacrylate monomers: Synthesis, characterisation and electro-optical properties

A number of liquid crystal monomers based on methacrylate derivatives were synthesised by novel mild and solventless procedures under microwave irradiation. Their photo- and thermo assisted homo- and co-polymerizations with glycidyl methacrylate were investigated. The resulting polymers were characterised by NMR, GPC, DSC, and SEM to determine their structures and properties. The effects of the structures of the monomers on the electro-optical properties were correlated. Copyright Taylor & Francis Group, LLC.

Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif

Forty-eight cationically substituted pentamidine congeners possessing benzofuran rings were synthesized by a copper mediated heteroannulation of substituted o-iodophenols with phenyl acetylenes. Activities of compounds 1-48 against Trypanosoma brucei rhod

2,3-diketopiperazine derivatives or their salts

The present invention relates to a 2,3-diketopiperazine derivative or a salt thereof, which has inhibitory effect on platelet aggregation because of glycoprotein IIb/IIIa receptor antagonism and hence is useful as a prophylactic and therapeutic agent for diseases associated with platelet aggregation. General formula: STR1 wherein R1 represents a protected or unprotected amidino group; R2 represents a hydrogen atom or a carboxyl-protecting group; A represents a substituted or unsubstituted lower alkylene group; B represents --O--, --CONH--, --NHCO--or --SO2 NH--; Y represents a substituted or unsubstituted lower alkylene group; and the broken line represents a single bond or a double bond.

Synthesis of potent non-imidazole histamine H3-receptor antagonists

Histamine has been converted into a non-imidazole H3-receptor histamine antagonist by addition of a 4-phenylbutyl group at the N(α)-position followed by removal of the imidazole ring. The resulting compound, N-ethyl- N-(4-phenylbutyl)amine, remarkably has a Ki = 1.3 μM as an H3 antagonist. Using this as a lead compound, a novel series of homologous O and S isosteric tertiary amines was synthesised and structure-activity studies furnished N- (5-phenoxypentyl)pyrrolidine (Ki = 0.18 ± 0.10 μM, for [3H]histamine release from rat cerebral cortex synaptosomes) which, more importantly, was active in vivo. Substitution of NO2 into the para position of the phenoxy group gave N-(5-p-nitrophenoxypentyl)pyrrolidine, UCL 1972 (Ki= 39 ± 11 nM), ED50 = 1.1 ± 0.6 mg/kg per os in mice on brain tele-methylhistamine levels.

Topologically Controlled Coulombic Interactions, a New Tool in the Developing of Novel Reactivity. Photochemical and Electrochemical Cleavage of Phenyl Alkyl Ethers

The hypothesis that a specific placement of a positive charge would dramatically alter the behavior of a charged intermediate has been tested.Phenyl ethers substituted by electron-attracting groups do not undergo reductive fragmentation.However, related α-piperidino-ω-(4-substituted-phenoxy)alkanes give alkyl ether photocleavage when the linker between the redox centers is short, or the usual substitution-reduction photochemistry when it is long.Mechanistic experiments suggest that the photofragmentation process operates through space intramolecular electron transfer to the triplet aromatic chromophore and that a coplanar relative orientation of the alkyl ether bond and the phenyl ring is compulsory for the photofragmentation to be observed.Configuration interaction AM1 calculations justify the described facts, indicating that the fragmentation process is only operative when a Coulombic stabilization of a ?* intramolecular electron transfer excited state is produced.Electrochemical studies carried out with the corresponding quaternary salts (intermolecular generation of the phenyl ether radical anion) confirm the conclusions derived from the photochemical experiments.