919482-09-0

Basic information

• Product Name: 4-(3-chloro-4-fluoro-phenylamino)-6-nitro-2-oxo-1,2-dihydro-quinoline-3-carbonitrile
• Synonyms: 4-(3-chloro-4-fluoro-phenylamino)-6-nitro-2-oxo-1,2-dihydro-quinoline-3-carbonitrile
• CAS NO: 919482-09-0
• Molecular Weight: 358.716
• Mol File: 919482-09-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-chloro-4-fluoro-phenylamino)-6-nitro-2-oxo-1,2-dihydro-quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-chloro-4-fluoro-phenylamino)-6-nitro-2-oxo-1,2-dihydro-quinoline-3-carbonitrile(919482-09-0)
• EPA Substance Registry System: 4-(3-chloro-4-fluoro-phenylamino)-6-nitro-2-oxo-1,2-dihydro-quinoline-3-carbonitrile(919482-09-0)

Safety Data

• Hazardous Substances Data: 919482-09-0(Hazardous Substances Data)

Upstream product

• 616-79-5 2-amino-5-nitro-benzoic acid 
• 3816-62-4 5-nitroanthranilic acid methyl ester 
• 84884-27-5 4-hydroxy-6-nitro-2-oxo-1,2-dihydro-quinoline-3-carbonitrile 
• 919482-08-9 4-chloro-6-nitro-2-oxo-1,2-dihydro-quinoline-3-carbonitrile 
• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 919482-10-3 6-amino-4-(3-chloro-4-fluoro-phenylamino)-2-oxo-1,2-dihydro-quinoline-3-carbonitrile 

Relevant articles and documents

Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis

The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2 kinase with selectivity against a panel of selected kinases in enzymatic assays and specificity in cell-based phosphorylation assays in LPS-treated human monocytes were identified. Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFα release when administered intraperitoneally in mice.