91958-13-3

Basic information

• Product Name: methyl 2-allyloxy-4-acetylaminobenzoate
• Synonyms: methyl 2-allyloxy-4-acetylaminobenzoate
• CAS NO: 91958-13-3
• Molecular Weight: 249.266
• Mol File: 91958-13-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 2-allyloxy-4-acetylaminobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-allyloxy-4-acetylaminobenzoate(91958-13-3)
• EPA Substance Registry System: methyl 2-allyloxy-4-acetylaminobenzoate(91958-13-3)

Safety Data

• Hazardous Substances Data: 91958-13-3(Hazardous Substances Data)

Upstream product

• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 106-95-6 allyl bromide 

Downstream Products

• 4093-28-1 methyl 4-acetamido-2-hydroxybenzoate 
• 1427164-05-3 N-(3-(allyloxy)-4-formylphenyl)acetamide 
• 1427164-04-2 N-(3-(allyloxy)-4-(hydroxymethyl)phenyl)acetamide 
• 175422-59-0 4-Acetylamino-3-allyl-5-chloro-2-ethoxy-benzoic acid methyl ester 
• 202664-64-0 4-Acetylamino-5-chloro-2-ethoxy-3-propyl-benzoic acid methyl ester 
• 129511-07-5 methyl 3-allyl-2-hydroxy-4-acetylamino-5-chlorobenzoate 
• 143878-29-9 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid methyl ester 
• 202664-60-6 4-Acetylamino-3-allyl-2-ethoxy-benzoic acid methyl ester 
• 202664-62-8 4-Acetylamino-5-chloro-2-methoxy-3-propyl-benzoic acid methyl ester 
• 129529-37-9 methyl 3-allyl-2-methoxy-4-acetylamino-5-chlorobenzoate 
• 202664-58-2 4-Acetylamino-3-allyl-2-methoxy-benzoic acid methyl ester 
• 202664-59-3 4-Acetylamino-2-methoxy-3-propyl-benzoic acid methyl ester 
• 149466-67-1 methyl 4-acetylamino-2,3-dihydrobenzo[b]furan-7-carboxylate 
• 202664-85-5 methyl 4-acetylamino-2-hydroxy-3-(2-hydroxyethyl)benzoate 

Relevant articles and documents

Substituted benzene and heterocyclic compound and its preparation method and application

The invention provides substituted benzoheterocyclic compounds and a preparation method thereof. The compounds have structures shown by formulas I and II. The invention also provides the effects of the compounds shown by formulas I and II in resisting virus, tumor and the like. The invention further provides a medicine composition taking the compounds shown by the formulas I and II as active ingredients, and the anti-virus or anti-tumor effect of the medicine composition. The invention lays a foundation for the future in-depth study and development of the anti-virus or anti-tumor medicine of the compounds.

Synthesis and structure-activity relationship of 3-substituted benzamide, benzo[b]furan-7-carboxamide, 2,3-dihydrobenzo[b]furan-7- carboxamide, and indole-5-carboxamide derivatives as selective serotonin 5- HT4 receptor agonists

The title compounds (6-9) were prepared and evaluated for serotonin 5- HT4 agonistic activity in in vitro tests. Introducing a propyl or allyl group at the 3-position of benzamide caused only a slight enhancement of agonistic activity. Construction of the benzo[b']furan skeleton and 2,3- dihydrobenzo[b]furan skeleton caused a significant enhancement of the activity. 4-Amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2- methylbenzo[b]furan-7-carboxamide (7b) hemifumarate was as potent as cisapride. 4-Amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2,3- dihydro-2-methylbenzo[b]furan-7-carboxamide (8a) hemifumarate, 4-amino-N-[2- (1-azabicyclo [3.3.0]octan-5-yl)ethyl]5-chloro-2,3-dihydro-2- ethylbenzo[b]furan-7-carboxamide (8c) hemifumarate, and 4-amino-N-]2-(1- azabicyclo[3.3.0]octan-5-yl]-5-chloro-2,3-dihydro-2,3-dimethylhenzo[b]furan- 7-carboxamide (8d) hemifumarate were more potent than cisapride. Furthermore, 8a hemifumarate was free from dopamine D1, D2, serotonin 5-HT1, 5-HT2 and muscarine M1, M2 receptor binding activity in the in vitro tests. On the other hand, construction of the indole skeleton caused a remarkable decrease in activity.

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