91962-68-4Relevant academic research and scientific papers
Potent, long-acting cyclopentane-1,3-dione thromboxane (A2)-receptor antagonists
Wang, Xiaozhao,Liu, Li,Huang, Longchuan,Herbst-Robinson, Katie,Cornec, Anne-Sophie,James, Michael J.,Sugiyama, Shimpei,Bassetto, Marcella,Brancale, Andrea,Trojanowski, John Q.,Lee, Virginia M.-Y.,Smith, Amos B.,Brunden, Kurt R.,Ballatore, Carlo
, p. 1015 - 1020 (2014)
A series of derivatives of the known thromboxane A2 prostanoid (TP) receptor antagonists, 3-(6-((4-chlorophenyl)sulfonamido)-5,6,7,8-tetrahydronaphthalen-1-yl)propanoic acid and 3-(3-(2-((4-chlorophenyl)sulfonamido)ethyl)phenyl) propanoic acid,
An efficient synthesis of 2-aryl-3-methoxy-2-cycloalkenones via Suzuki-Miyaura reaction under microwave irradiation
Song, Young Seob,Kim, Bum Tae,Heo, Jung-Nyoung
, p. 5987 - 5990 (2005)
The Suzuki-Miyaura coupling reaction of α-bromocycloalkenones with arylboronic acids has been developed by using microwave heating. This method provides a simple and rapid construction of small molecule libraries of α-arylcycloalkenones with high efficiency.
Asymmetric synthesis of 1,2,3-trisubstituted cyclopentanes and cyclohexanes as key components of substance P antagonists
Kuethe, Jeffrey T.,Wong, Audrey,Wu, Jimmy,Davies, Ian W.,Dormer, Peter G.,Welch, Christopher J.,Hillier, Michael C.,Hughes, David L.,Reider, Paul J.
, p. 5993 - 6000 (2007/10/03)
An efficient asymmetric synthesis of 1,2,3-trisubstituted cyclopentanes and cyclohexanes is described. Three methods were developed for the preparation of the 2,3-disubstituted cyclopentenones and cyclohexenones, which are key achiral building blocks. These intermediates are reduced catalytically with (R)-2-methyloxazaborolidine in high yield (82-98%) and excellent ee (89-96%). Directed reduction of the chiral allylic alcohols using Red-Al gives exclusively the 1,2-anti stereochemistry (>99:1). Epimerization of the ester center followed by saponification/crystallization affords the desired hydroxyacids in good yield (65-70%) and in high enantiomeric excess (>99%).
