91971-18-5

Usage

Uses

Ethanone, 1-[2-methoxy-6-(methoxymethoxy)phenyl]is used as a chemical intermediate for the synthesis of various organic compounds. Its unique molecular structure with methoxy and methoxymethoxy groups may provide it with specific reactivity and properties that can be exploited in the development of new materials and pharmaceuticals.
Used in Pharmaceutical Industry:
Ethanone, 1-[2-methoxy-6-(methoxymethoxy)phenyl]is used as a potential active pharmaceutical ingredient for the development of new drugs. Its distinctive molecular structure may offer unique interactions with biological targets, leading to the discovery of novel therapeutic agents.
Used in Material Science:
Ethanone, 1-[2-methoxy-6-(methoxymethoxy)phenyl]is used as a building block for the creation of new materials with specific properties. Its chemical structure may allow for the formation of novel polymers, coatings, or other materials with applications in various industries.
Used in Research and Development:
Ethanone, 1-[2-methoxy-6-(methoxymethoxy)phenyl]is used as a research compound for studying its chemical properties, reactivity, and potential applications. Further research is needed to fully understand its characteristics and explore its potential uses in various fields.

Upstream product

• 703-23-1 2'-hydroxy-6'-methoxyacetophenone 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 105285-15-2 (2R^*,3R^*)-4'-hydroxy-5-methoxyflavanonol 
• 110168-87-1 3-chloro-2-hydroxy-1-2''-hydroxy-6''-methoxyphenyl-3,4'-methoxyphenylpropanone 
• 110168-81-5 2,3-epoxy-1-6''methoxy-2''-methoxymethoxyphenyl-3-4'-methoxyphenylpropanone 
• 110168-78-0 2,3-epoxy-1-6''-methoxy-2''-methoxymethoxyphenyl-3-4'-methoxymethoxyphenylpropanone 
• 110168-85-9 2-hydroxy-1-2''-hydroxy-6''-methoxyphenyl-3-methoxy-3,4'-methoxyphenylpropanone 
• 110168-85-9 2-hydroxy-1-2''-hydroxy-6''-methoxyphenyl-3-methoxy-3,4'-methoxyphenylpropanone 
• 105285-14-1 4,2'-dihydroxy-6'-methoxychalcone 
• 110168-76-8 4,6'-dimethoxy-2'-methoxymethoxychalcone 
• 110168-73-5 4,2'-bis(methoxymethoxy)-6'-methoxychalcone 

Relevant academic research and scientific papers

Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues

Aldose reductase, the key enzyme of the polyol pathway, and oxidative stress are known to play important roles in the complications of diabetes. A drug with potent inhibition of aldose reductase and oxidative stress, therefore, would be a most promising drug for the prevention of diabetic complications. The purpose of this study was to develop new compounds with these dual-effects through synthesis of chalcone derivatives and by examining the structure-activity relationships on the inhibition of rat lens aldose reductase as well as on antioxidant effects. A series of 35 flavonoid derivatives were synthesized by Winget's condensation, oxidation, and reduction of appropriate acetophenones with appropriate benzaldehydes. The inhibitory activity of these derivatives on rat lens aldose reductase and their antioxidant effects, measured using Cu2+ chelation and radical scavenging activities on 1,1-diphenyl-picrylhydrazyl in-vitro, were evaluated. Their effect on sorbitol accumulation in the red blood cells, lenses and sciatic nerves of streptozotocin-induced diabetic rats was also estimated. Among the new flavonoid derivatives synthesized, those with the 2′,4′-dihydroxyl groups in the A ring such as 2,4,2′,4′-tetrahydroxychalcone (22), 2,2′,4′-trihydroxychalcone (11), 2′,4′-dihydroxy-2,4-dimethylchalcone (21) and 3,4,2′,4′-tetrahydroxychalcone (18) were found to possess the highest rat lens aldose reductase inhibitory activity in-vitro, their IC50 values (concentration of inhibitors giving 50 % inhibition of enzyme activity) being 1.6 × 10-7, 3.8 × 10-7, 4.0 × 10-7 and 4.6 × 10-7 M, respectively. All of the chalcones tested except 3, 18, 23 with o-dihydroxy or hydroquinone moiety showed a weak free radical scavenging activity. In the in-vivo experiments, however, compound 18 with o-dihydroxy moiety in the B ring showed the strongest inhibitory activity in the accumulation of sorbitol in the tissues. It also showed the strongest activity in transition metal chelation and free radical scavenging activity. Of the 35 4,2′-dihydroxyl and 2′,4′-dihydroxyl derivatives of flavonoid synthesized, including chalcone, flavone, flavanone, flavonol and dihydrochalcone, some chalcone derivatives synthesized were found to possess aldose reductase inhibition and antioxidant activities in-vitro as well as inhibition in the accumulation of sorbitol in the tissues in-vivo. 3,4,2′,4′-Tetrahydroxychalcone (18, butein) was the most promising compound for the prevention or treatment of diabetic complications.

PYRIDYLPHENOL COMPOUND AND USE THEREOF

The present invention provides a compound which has metastin receptor antagonist activity and is useful for preventing and treating hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, uterine myoma or the like. More specifically, the present invention provides a compound, represented by the formula: or a salt thereof, a prodrug thereof, and a pharmaceutical agent containing the same; wherein Ring A represents a 5- to 8-membered homocyclic or heterocyclic group optionally having a substituent other than formula -X-R1 wherein X represents a bond or a spacer, and R1 represents optionally substituted amino or an optionally substituted nitrogen-containing heterocyclic group; Ring B represents an optionally substituted benzene ring; R2 represents an optionally substituted homocyclic or heterocyclic group; and R3 and R4 independently represent a hydrogen atom, cyano, acyl or an optionally substituted hydrocarbon group.

Heterocycles. XX. Reactions of 2''-Methoxymethoxychalcone Epoxides under Acidic Conditions

The effect of substituents on the formation of products in the reactions of 2''-methoxymethoxychalcone epoxides under acidic conditions has been examined.Regardless of the 6''-substituent, the presence of a 4'-hydroxyl group results in the exlusive format