919746-95-5Relevant academic research and scientific papers
Design, synthesis and molecular docking of novel structural hybrids of substituted isatin based pyrazoline and thiadiazoline as antitumor agents
Gangarapu, Kiran,Thumma, Gouthami,Manda, Sarangapani,Jallapally, Anvesh,Jarapula, Ravi,Rekulapally, Sriram
, p. 819 - 829 (2017)
Cancer, which is considered to be the world’s most serious illness cause 8.2 million deaths and this rate may double by 2030. We herein report a new series of 3-(2-(p-substituted)-2-((5-phenyl-1,3,4-thiadiazol-2-yl)imino)-2-(p-substituted)ethylidene)indolin-2-one (15–19) and 5-substituted-5′-substituted phenyl-2′,4′-dihydrospiro[indoline-3,3′-pyrazol]-2-one derivatives (20–24) as potent anticancer agents. These compounds were evaluated for in vitro antitumor activity against the National Cancer Institute panel of 60 cancer cell lines. Among all the synthesized compounds, two compounds 15 and 16 showed remarkable antitumor activity with GI50 (MG-MID) values of 0.65 & 0.72 μM, respectively against Non-small cell lung cancer. To gain insight for mode of binding with Epidermal Growth Factor Receptor kinase enzyme, these compounds were further subjected to docking studies.
Spiro indolone compound as well as, preparation, method and pharmaceutical composition and application thereof
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Paragraph 0250; 0259-0262; 0295-0298, (2020/01/11)
Spiro indolone compounds, a preparing method, a medicine composition and uses of the compounds are disclosed. In particular, the invention provide spiro indolone compounds shown as a formula I or II, a preparing method of the spiro indolone compounds and
Synthesis of spiro heterocyclic compounds
Ibrahim, Mohamed N.,El-Messmary, Mohamed F.,Elarfi, Mohamed G.A.
experimental part, p. 55 - 58 (2011/01/03)
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III). Condensation of (III) with hydrazine hydrate, phenylhydrazine and phenylthiourea
One-pot synthesis of new spiro[cyclopropane-1,3′-[3H]indol]- 2′(1′H)-ones from 3-phenacylideneoxindoles
Shaabanzadeh, Masoud,Khabari, Faranak
experimental part, p. 949 - 953 (2010/09/03)
(Chemical Equation Presented) In a one-pot procedure, the 3-phenacylideneoxindoles 1a-d were reacted with hydrazine and then in situ with lead(IV) acetate and new diastereoisomers of spiro[cyclopropane-1,3′-[3H] indol]-2′(1′H)-ones were prepared. Compounds 1a-d underwent a highly diastereoselective cyclopropanation leading to diastereoisomers 2a-d. These new compounds containing both 2-oxindole and cyclopropane moieties may be valuable in medicinal chemistry.
