919765-23-4Relevant academic research and scientific papers
Regioselectively N-methylated azacalix[8]arene octamethyl ether prepared by catalytic aryl amination reaction using a temporal N-silylation protocol
Ishibashi, Koichi,Tsue, Hirohito,Tokita, Satoshi,Matsui, Kazuhiro,Takahashi, Hiroki,Tamura, Rui
, p. 5991 - 5994 (2006)
(Chemical Equation Presented) A temporal N-silylation protocol in the catalytic aryl amination reaction has been devised to prepare nitrogen-bridged calixarene analogues. The protocol involves a smooth in situ N-silylation before aryl amination reaction, followed by spontaneous cleavage of the N-Si bond in the usual workup process, to furnish secondary aromatic amines as the cross-coupled product with no silyl group on the nitrogen atom. A successful application to the preparation of regioselectively N-methylated azacalix[8]arene is described, together with the crystallographic analysis.
