91977-33-2Relevant academic research and scientific papers
Acid-Catalyzed Reaction of (4,4-Diethoxybutyl)ureas with Phenols as a Novel Approach to the Synthesis of α-Arylpyrrolidines
Gazizov, Almir S.,Smolobochkin, Andrey V.,Voronina, Julia K.,Burilov, Alexander R.,Pudovik, Michail A.
, p. 1215 - 1221 (2015)
1-(4,4-Diethoxybutyl)-3-alkylureas undergo intramolecular cyclization in the presence of trifluoroacetic acid and various phenols, leading to the new N-alkyl-2-arylpyrrolidine-1-carboxamides with moderate to excellent yields. It was found that these compo
Catalytic Site-Selective Carbamoylation of Pyranosides
Alsarraf, Jér?me,Petitpoisson, Lucas,Pichette, André
supporting information, p. 6052 - 6056 (2021/08/03)
Carbamate-bearing carbohydrates contribute to the pharmacological properties of various natural glycosides. The catalytic site-selective carbamoylation of minimally protected pyranosides was achieved for the first time to bypass protection/deprotection sequences. 1-Carbamoylimidazoles were used as the carbamoylation reagents to circumvent the harmful and unstable phosgene and isocyanates. This borinic acid catalyzed transformation granted an expedient access to the tumor cell-binding carbamoylmannoside moiety of bleomycins and analogs in yields of 56% to 89%.
Solvent-Free Synthesis of Cyanoformamides from Carbamoyl Imidazoles
Nugent, Jeremy,Campbell, Sarah G.,Vo, Yen,Schwartz, Brett D.
, p. 5110 - 5118 (2017/09/23)
A straightforward and solvent-free synthesis of various secondary and tertiary cyanoformamides from carbamoyl imidazoles and TMSCN has been developed. Both cyclic and acyclic carbamoyl imidazoles react smoothly to form the relevant cyanoformamides in excellent yields, often within minutes.
