91982-84-2Relevant academic research and scientific papers
Synthesis and biological evaluation of a novel phenyl substituted sydnone series as potential antitumor agents
Dunkley, Christopher S.,Thoman, Charles J.
, p. 2899 - 2901 (2007/10/03)
A series of compounds containing an N-(4′-substituted-3′- nitrophenyl)sydnone moiety with potential antitumor activity was prepared based on active analogues. The rationale behind the design of these compounds is presented along with the 4-step synthetic route to the derivatives in the 4′-position of the phenyl sydnone framework. Out of the six novel compounds, the 4′-fluoro derivative has an improved activity against all three cell lines as compared to the earlier leads.
