91985-98-7Relevant academic research and scientific papers
Redox couple involving NOx in aerobic Pd-catalyzed oxidation of sp3-C-H bonds: Direct Evidence for Pd-NO3-/NO2- interactions involved in oxidation and reductive elimination
Wenzel, Margot N.,Owens, Philippa K.,Bray, Joshua T.W.,Lynam, Jason M.,Aguiar, Pedro M.,Reed, Christopher,Lee, James D.,Hamilton, Jacqueline F.,Whitwood, Adrian C.,Fairlamb, Ian J.S.
, p. 1177 - 1190 (2017)
NaNO3 is used in oxidative Pd-catalyzed processes as a complementary co-catalyst to common oxidants, e.g., CuII salts, in C-H bond activation and Wacker oxidation processes. NaNO3 and NaNO2 (with air or O2
Carboxylation of a Palladacycle Formed via C(sp3)?H Activation: Theory-Driven Reaction Design
Kanna, Wataru,Harabuchi, Yu,Takano, Hideaki,Hayashi, Hiroki,Maeda, Satoshi,Mita, Tsuyoshi
, p. 4072 - 4080 (2021/11/01)
Theory-driven organic synthesis is a powerful tool for developing new organic transformations. A palladacycle(II), generated from 8-methylquinoline via C(sp3)?H activation, is frequently featured in the scientific literature, albeit that the reactivity toward CO2, an abundant, inexpensive, and non-toxic chemical, remains elusive. We have theoretically discovered potential carboxylation pathways using the artificial force induced reaction (AFIR) method, a density-functional-theory (DFT)-based automated reaction path search method. The thus obtained results suggest that the reduction of Pd(II) to Pd(I) is key to promote the insertion of CO2. Based on these computational findings, we employed various one-electron reductants, such as Cp*2Co, a photoredox catalyst under blue LED irradiation, and reductive electrolysis ((+)Mg/(?)Pt), which afforded the desired carboxylated products in high yields. After screening phosphine ligands under photoredox conditions, we discovered that bidentate ligands such as dppe promoted this carboxylation efficiently, which was rationally interpreted in terms of the redox potential of the Pd(II)-dppe complex as well as on the grounds of DFT calculations. We are convinced that these results could serve as future guidelines for the development of Pd(II)-catalyzed C(sp3)?H carboxylation reactions with CO2.
