919940-74-2Relevant academic research and scientific papers
Sodium chlorate as a viable substoichiometric oxidant for cobalt-catalyzed oxidative annulation of aryl sulfonamides with alkynes
Ran, You,Yang, Yudong,Zhang, Luoqiang
supporting information, p. 3322 - 3325 (2016/07/11)
In this work, NaClO3is demonstrated for the first time as an efficient and versatile oxidant in the catalytic C–H activation reaction. By using sodium chlorate as the oxidant, a highly regioselective cobalt-catalyzed oxidative annulation of ary
Novel Sulfonaminoquinoline Hepcidin Antagonists
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Page/Page column 134, (2012/09/05)
The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
From sensors to silencers: Quinoline- and benzimidazole-sulfonamides as inhibitors for zinc proteases
Rouffet, Matthieu,De Oliveira, Cesar Augusto F.,Udi, Yael,Agrawal, Arpita,Sagi, Irit,McCammon, J. Andrew,Cohen, Seth M.
supporting information; experimental part, p. 8232 - 8233 (2010/08/05)
Derived from the extensive work in the area of small molecule zinc(II) ion sensors, chelating fragment libraries of quinoline- and benzimidazole- sulfonamides have been prepared and screened against several different zinc(II)-dependent matrix metalloproteinases (MMPs). The fragments show impressive inhibition of these metalloenzymes and preferences for different MMPs based on the nature of the chelating group. The findings show that focused chelator libraries are a powerful strategy for the discovery of lead fragments for metalloprotein inhibition.
