919995-76-9Relevant academic research and scientific papers
Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors
Deprez-Poulain, Rebecca,Flipo, Marion,Piveteau, Catherine,Leroux, Florence,Dassonneville, Sandrine,Florent, Isabelle,Maes, Louis,Cos, Paul,Deprez, Benoit
, p. 10909 - 10917 (2013/03/14)
Malaria is a severe infectious disease that causes between 655 000 and 1.2 million deaths annually. To overcome the resistance to current drugs, new biological targets are needed for drug development. Aminopeptidase M1 (PfAM1), a zinc metalloprotease, has
A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening
Flipo, Marion,Beghyn, Terence,Charton, Julie,Leroux, Virginie A.,Deprez, Benoit P.,Deprez-Poulain, Rebecca F.
, p. 63 - 76 (2007/10/03)
We report here the design and parallel synthesis of 217 compounds based on a malonic-hydroxamic acid template. These compounds are obtained via a two-step solution-phase procedure. The set of diverse building-blocks used makes this strategy suitable for t
