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2'-Hydroxy-5'-phenylpropiophenone, also known as 2-(2-hydroxyphenyl)-1-(4-phenyl)ethanone, is an organic compound with the molecular formula C15H12O2. It is a derivative of propiophenone, featuring a hydroxyl group at the 2' position and a phenyl group at the 5' position. This chemical is characterized by its white crystalline appearance and is soluble in organic solvents. It is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly in the production of certain benzodiazepines and other therapeutic agents. Due to its potential applications in the creation of psychoactive substances, it is subject to regulatory controls in some jurisdictions.

92-08-0

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92-08-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 92-08-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 92-08:
(4*9)+(3*2)+(2*0)+(1*8)=50
50 % 10 = 0
So 92-08-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O2/c16-14(11-12-7-3-1-4-8-12)15(17)13-9-5-2-6-10-13/h1-10,14,16H,11H2

92-08-0Relevant academic research and scientific papers

An Enolate-Structure-Enabled Anionic Cascade Cyclization Reaction: Easy Access to Complex Scaffolds with Contiguous Six-, Five-, and Four-Membered Rings

Buk?naitien?, Rita,Javorskis, Tomas,Jurys, Arminas,Karpavi?ien?, Ieva,Orentas, Edvinas,Snarskis, Gustautas

supporting information, p. 20120 - 20128 (2020/09/02)

Catalyst-free addition of ketone enolate to non-activated multiple C?C bonds involves non-complementary reaction partners and typically requires super-basic conditions. On the other hand, highly aggregated or solvated enolates are not reactive enough to undergo direct addition to alkenes or alkynes. Herein, we report a new anionic cascade reaction for one-step assembly of intriguing molecular scaffolds possessing contiguous six-, five-, and four-membered rings, representing a formal [2+2] enol–allene cycloaddition. Reaction proceeds under very mild conditions and with excellent diastereoselectivity. Deeper mechanistic and computational studies revealed unusually slow proton transfer phenomenon in cyclic ketone intermediate and explained peculiar stereochemical outcome.

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