92-49-9

Basic information

• Product Name: N-Chloroethyl-N-ethylaniline
• Synonyms: N-ETHYL-N-CHLOROETHYL ANILINE;N-CHLOROETHYL-N-ETHYLANILINE;2-(n-ethylanilino)ethylchloride;4-chloro-n,n-diethyl-anilin;emery5770;ethyl(chloroethyl)aniline;n-(2-chloroethyl)-n-ethyl-anilin;n-(2-chloroethyl)-n-ethyl-benzenamin
• CAS NO: 92-49-9
• Molecular Formula: C₁₀H₁₄ClN
• Molecular Weight: 183.68
• EINECS: 202-159-3
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 92-49-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 46°C
• Boiling Point: 302.39°C (rough estimate)
• Flash Point: 110.8 °C
• Appearance: /
• Density: 1.0821 (rough estimate)
• Vapor Pressure: 0.0128mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• CAS DataBase Reference: N-Chloroethyl-N-ethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-Chloroethyl-N-ethylaniline(92-49-9)
• EPA Substance Registry System: N-Chloroethyl-N-ethylaniline(92-49-9)

Safety Data

• Hazardous Substances Data: 92-49-9(Hazardous Substances Data)

Usage

General Description

N-Chloroethyl-N-ethylaniline is a chemical compound with the molecular formula C10H14ClN. It is a pale yellow liquid that is primarily used as an intermediate in the production of dyes, pigments, and pharmaceuticals. N-Chloroethyl-N-ethylaniline is also used as a corrosion inhibitor and as an intermediate in the synthesis of other organic compounds. N-Chloroethyl-N-ethylaniline is toxic and can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. It should be handled and stored with proper safety precautions to prevent any harmful effects on human health and the environment.

InChI:InChI=1/C10H14ClN/c1-2-12(9-8-11)10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3

Upstream product

• 103-69-5 N-ethyl-N-phenylamine 
• 92-50-2 2-( N-ethylanilino)ethanol 

Downstream Products

• 132570-11-7 1-acetyl-4-[2-(N-ethyl-anilino)-ethyl]-piperazine 
• 113091-12-6 1-[2-(N-ethyl-anilino)-ethyl]-4-[2]pyridyl-piperazine 
• 150591-05-2 2-[2-(Ethyl-phenyl-amino)-ethyl]-isothiourea 
• 89787-44-0 2-(2-{4-[(2-Chloro-ethyl)-ethyl-amino]-phenylazo}-benzothiazol-6-yloxy)-ethanol 
• 869340-97-6 di[2-(N-ethylanilino)ethyl] 5-aminoisophthalate 
• 55619-06-2 N-(2-chloroethyl)-N-ethyl-4-[(4-nitrophenyl)azo]aniline 
• 1452855-70-7 4-((2-(ethyl(phenyl)amino)ethyl)thio)phenol 
• 1391754-39-4 C₁₄H₁₃ClN₄O₂ 
• 1084890-31-2 N-(2-azidoethyl)-N-ethylaniline 
• 1310012-55-5 3-{2-[ethyl(phenyl)amino]ethoxy}phenol 
• 1310012-54-4 4-{2-[ethyl(phenyl)amino]ethoxy}phenol 
• 1369385-59-0 2-{2-[ethyl(phenyl)amino]ethoxy}phenol 
• 123871-38-5 N-ethyl-N-[2-(4-methoxyphenoxy)ethyl]aniline 
• 54117-10-1 N-[2-(N-ethyl-anilino)-ethyl]-methanesulfonamide 

Relevant articles and documents

Development of new nonlinear optical polymers based on epoxy- amine oligomers with Bi-chromophore fragments in the side chain

For the first time bichromophore nonlinear optically active compounds, 3,5-bis [2- (N-ethyl-4- (4′-nitrophenylazo) anilino) ethoxy] benzyl alcohol, DF1, and 3,5-bis [6- (N-methyl-4- (4′-nitrophenylazo) anilino) hexaoxy] benzyl alcohol, DF2, have been synthesized. The synthesis of the epoxy-amine oligomers containing DF1 and DF2 dendritic fragments in the side chain was preceded by molecular design which demonstrated that the hexyl groups, binding the chromophores to the branching center in DF2, are able to provide greater mobility of the chromophores compared to the ethyl groups in DF1, thus determining the preference of the former from the viewpoint of NLO activity. Bi-chromophore compounds were introduced into the side chain of epoxy amine oligomers using the esterification reaction under mild conditions by the Steglich method. As a result, oligomers OAB-DF1 (Tg = 122 °C) and OAB-DF2 (Tg = 107 °C) were obtained with good yields, the degree of functionalization was 60 mol% and 45 mol%, respectively. The values of the NLO coefficients, d33, were measured by second harmonic generation technique; they are equal to 29 pm/V for OAB-DF1 and 40 pm/V for OAB-DF2.

New "X-type" second-order nonlinear optical (NLO) dendrimers: Fewer chromophore moieties and high NLO effects

New types of "X-type" NLO dendrimers, C2 and C3, in which the chromophore moieties were arranged in order, were rationally designed. The special topology of the chromophore moieties contributed a great deal to the good NLO performance of C2 and C3: the d33 value of C2 (containing only five chromophore moieties) was 157.4 pm V-1, while that of C3 (containing nine chromophore moieties) achieved 195.2 pm V-1, much larger than that of C1 (74.7 pm V-1, containing three chromophore moieties) and the fifth generation dendrimer (G5) (193.1 pm V-1, bearing 62 pieces of chromophore moieties). Through careful experimental and theoretical analysis, their structure-property relationship was explained, and discussed in detail.

ROS-Activated Compounds as Selective Anti-Cancer Therapeutics

Provided are compounds according to the following Formula I: The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.