92-68-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
4-Cyclohexylcyclohexanone is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new and effective products in these industries.
Used in Fragrance and Flavor Compound Synthesis:
4-CYCLOHEXYLCYCLOHEXANONE is utilized as a building block in the creation of fragrance and flavor compounds, enhancing the sensory profiles of consumer products.
Used in Polymer and Plastics Industry:
4-Cyclohexylcyclohexanone is used as a stabilizer in the production of polymers and plastics, ensuring the quality and longevity of these materials.
Used in Chemical Industry as an Intermediate:
As an important intermediate, 4-cyclohexylcyclohexanone is instrumental in the synthesis of a range of other organic compounds, highlighting its versatility and value in the chemical sector.

Upstream product

• 92-69-3 4-Phenylphenol 
• 4894-75-1 1-phenyl-4-cyclohexanone 
• 2433-14-9 bicyclohexyl-4-ol 
• 92-67-1 4-phenylalanine 
• 120982-19-6 8-Cyclohexyl-1,4-dithia-spiro[4.5]decane 
• 66405-57-0 1,1'-bicyclohexyliden-4-one 
• 7335-42-4 trans-4-cyclohexylcyclohexanol 
• 7335-11-7 cis-4-cyclohexylcyclohexanol 
• 56309-94-5 8-(4-oxocyclohexyl)-1,4-dioxaspiro[4.5]decane 
• 20818-96-6 8-cyclohexyl-1,4-dioxaspiro[4.5]decane 

Downstream Products

• 102662-70-4 3,5-bis-[(Ξ)-[2]thienylmethylene-bicyclohexyl-4-one 
• 102597-04-6 2-cyclohexyl-7-methyl-1,2,3,4-tetrahydro-acridine-9-carboxylic acid 
• 102156-37-6 2-cyclohexyl-1,2,3,4-tetrahydro-acridine-9-carboxylic acid 
• 102461-38-1 7-bromo-2-cyclohexyl-1,2,3,4-tetrahydro-acridine-9-carboxylic acid 
• 103331-22-2 3,5-bis-[1]naphthylmethylene-bicyclohexyl-4-one 
• 35962-17-5 (4-cyclohexyl-cyclohex-1-enyl)-acetic acid ethyl ester 
• 3363-80-2 4-cyclohexyl-1-p-tolyl-cyclohexene 
• 39000-65-2 1,4-dicyclohexyl-cyclohexene 
• 98904-08-6 6-chloro-4'-cyclohexyl-1,1-dioxo-1,4-dihydro-2H-1λ⁶-spiro[benzo[1,2,4]thiadiazine-3,1'-cyclohexane]-7-sulfonic acid amide 
• 132292-26-3 1-carboxy-1'-hydroxy-1,1':4',1''-tercyclohexan-4-one ethylene ketal 
• 185537-81-9 9-(4-cyclohexyl-1-hydroxycyclohexanyl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid 

Relevant academic research and scientific papers

Construction of Distant Stereocenters by Enantioselective Desymmetrizing Carbonyl-Ene Reaction

An efficient desymmetrizing carbonyl-ene reaction of 1-substituted 4-methylenecyclohexanes with glyoxal derivatives was thus executed by a chiral N,N′-dioxide/NiII catalyst, providing facile access to cyclohexene derivatives bearing two remote 1,6-related stereocenters. This distal stereocontrol methodology originates from the efficient interaction between the catalyst with enophiles, discrimination of the two chair conformations of olefinic components, and the intrinsic six-membered transition-state structure of ene process.

NOVEL GLP-1 RECEPTOR MODULATORS

Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36), GLP-1(9-36), and oxyntomodulin, or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where "?" represents either or both the R and S form of the compound): where A, B, C, R1, R2, R3, R4, R5, n, p and q are as defined herein.

Synthesis and evaluations of GLP-1 secretion and anti-diabetic effect in KKAy mice of new tricyclic compounds

Glucagon-like peptide-1 (GLP-1), which belongs to the family of incretins, plays important role for the regulation of plasma glucose. Accordingly, GLP-1-based therapies for type 2 diabetes have recognized as one of the most interesting target. In this study, we have found the new tricyclic compounds having strong GLP-1 secretion from human intestinal L cells, and anti-diabetic properties in spontaneously obese and diabetic KKAy mice. The most potent compound 5ka was obtained as the unexpected product, and we would like to report the details of the synthesis, structure elucidations, pharmacological activities on secretion of GLP-1, and anti-diabetic effects using diabetic KKAy mice.

Highly Selective Hydrogenation of Aromatic Ketones and Phenols Enabled by Cyclic (Amino)(alkyl)carbene Rhodium Complexes

Air-stable Rh complexes ligated by strongly σ-donating cyclic (amino)(alkyl)carbenes (CAACs) show unique catalytic activity for the selective hydrogenation of aromatic ketones and phenols by reducing the aryl groups. The use of CAAC ligands is essential for achieving high selectivity and conversion. This method is characterized by its good compatibility with unsaturated ketones, esters, carboxylic acids, amides, and amino acids and is scalable without detriment to its efficiency.

Rhodium-on-carbon catalyzed hydrogen scavenger- and oxidant-free dehydrogenation of alcohols in aqueous media

The efficient and catalytic dehydrogenation of alcohols is a clean approach for preparing carbonyl compounds accompanied only by the generation of hydrogen gas. We have accomplished the heterogeneous rhodium-on-carbon catalyzed dehydrogenation of secondary, as well as primary, alcohols to the corresponding ketones and carboxylic acids in water under basic conditions. This journal is the Partner Organisations 2014.

The catalytic asymmetric Fischer indolization

The first catalytic asymmetric Fischer indolization is reported. In the presence of a 5 mol % loading of a novel spirocyclic chiral phosphoric acid, 4-substituted cyclohexanone-derived phenylhydrazones undergo a highly enantioselective indolization. Efficient catalyst turnover was achieved by the addition of a weakly acidic cation exchange resin, which removes the generated ammonia. The reaction can be conducted under mild conditions and gives various 3-substituted tetrahydrocarbazoles in generally high yields.

Process for producing alicyclic monoketones and process for producing alicyclic diketones

The process for producing alicyclic monoketones (hydroxyphenylcyclohexanone derivatives) according to the present invention comprises hydrogenating substituted bisphenols such as bisphenol A in a solvent in the presence of a palladium/alkali metal catalyst in which palladium and an alkali metal are both supported on a carrier to obtain alicyclic monoketones such as 2-(4-oxocyclohexyl)-2-(4-hydroxyphenyl)propane. The process for producing alicyclic diketones according to the present invention comprises hydrogenating substituted bisphenols such as bisphenol A in a solvent in the presence of a palladium/alkali metal catalyst in which palladium and an alkali metal are both supported on a carrier to obtain alicyclic diketones such as 2,2-bis(4-oxocyclohexyl)propane and 4,4′-bicyclohexanone. The other process for producing alicyclic monoketones according to the present invention comprises hydrogenating biphenols such as bis(4-hydroxyphenyl) in an organic solvent in the presence of a palladium catalyst in which 10 to 30% by weight of palladium is supported on a carrier to obtain alicyclic monoketones such as 4(4′-hydroxyphenyl)cyclohexanone. According to the present invention, alicyclic monoketones or alicyclic diketones can be obtained with high selectivity and in high yields through simple steps, because the process includes only one reaction step to hydrogenate substituted bisphenols under relatively mild conditions.

Amidino derivatives useful as nitric oxide synthase inhibitors

The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

Amidino dervatives useful as nitric oxide synthase inhibitors

The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.

Oligo(cyclohexylidene) oximes and derivatives as probe molecules for long-range substituent effects on13C NMR chemical shifts

For a series of rodlike aliphatic oximes (1-4) the influence of the oxime substituent on the 13C NMR chemical shifts has been studied. Various 2D NMR techniques were applied for the unequivocal assignment of their 1H and 13C resonances. For bicyclohexylidene oximes 1-2 long-range substituent effects on the 13C NMR chemical shifts of aliphatic carbon atoms of the six-membered rings due to the presence of the oxime group are discernible up to positions six carbon-carbon bonds distant from the iminyl carbon! The 13C NMR data obtained for bicyclohexyl oximes 3-4 reveal that in this series the effect is limited to carbon atoms which are five bonds distant from the iminyl carbon. The observed differences between the two series is attributed to the presence of an olefinic double bond in 1-2, whch becomes polarized by the electric field of the oxime substituent.