92001-52-0

Basic information

• Product Name: 6-CHLORO-8-METHYL-PURINE
• Synonyms: 6-CHLORO-8-METHYL-PURINE;6-chloro-8-Methyl-7H-purine;9H-Purine,6-chloro-8-Methyl-;6-chloro-8-methyl-1H-purine
• CAS NO: 92001-52-0
• Molecular Formula: C₆H₅ClN₄
• Molecular Weight: 168.583700
• Mol File: 92001-52-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 415 °C at 760 mmHg
• Flash Point: 237.2 °C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.781
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-CHLORO-8-METHYL-PURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-8-METHYL-PURINE(92001-52-0)
• EPA Substance Registry System: 6-CHLORO-8-METHYL-PURINE(92001-52-0)

Safety Data

• Hazardous Substances Data: 92001-52-0(Hazardous Substances Data)

Usage

General Description

6-Chloro-8-methyl-purine is a chemical compound with the molecular formula C6H5ClN4. It belongs to the purine family of organic compounds and is derived from the nucleobase adenine. It is a white crystalline powder with a molecular weight of 170.583 g/mol and a melting point of 230-233°C. This chemical is commonly used as a building block in the synthesis of pharmaceutical compounds, including anti-cancer and anti-viral drugs. It also has potential applications in the field of material science, particularly in the development of organic semiconductors. 6-Chloro-8-methyl-purine is a versatile and important chemical compound with various industrial and pharmaceutical uses.

InChI:InChI=1/C6H5ClN4/c1-3-10-4-5(7)8-2-9-6(4)11-3/h2,4H,1H3

Upstream product

• 50609-15-9 5-acetylamino-4-amino-6-oxo-1,6-dihydropyrimidine 
• 239784-24-8 6-chloro-8-methyl-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine 
• 218431-07-3 6,8-dichloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 
• 4316-98-7 6-chloro-4,5-diaminopyrimidine 
• 108-24-7 acetic anhydride 
• 1445-45-0 Trimethyl orthoacetate 

Downstream Products

• 1393180-99-8 (S)-8-methyl-N-(1-(1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine 
• 1008-51-1 8-methyl-6-methylsulfanyl-7(9)H-purine 
• 1126-23-4 8-methyl-1,7-dihydro-purine-6-thione 
• 22387-37-7 8-methyladenine 

Relevant articles and documents

Design and optimization of purine derivatives as in vivo active PDE10A inhibitors

Phosphodiesterases are important enzymes regulating signal transduction mediated by second messenger molecules cAMP or cGMP. PDE10A is a unique member in the PDE family because of its selective expression in medium spiny neurons. It is recognized as anti-psychotic drug target. Based on the structural similarity between our previous chemistry work on 8-aminoimidazo[1,2-a]pyrazines and the PDE10A inhibitors reported by Bartolome-Nebreda et al., we initialized a project for developing PDE10A inhibitors. After several rounds of optimization, we were able to obtain a few compounds with good PDE10A enzymatic activity. And after further PDE enzymatic selectivity study, metabolic stability assay and in vivo pharmacological tests we identified two inhibitors as interesting lead compounds with the potential for further PDE10A lead optimizatioin.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Specificity of the 1-Methyladenine Receptors in Starfish Oocytes: Synthesis and Properties of Some 1,8-Disubstituted Adenines, 1,6-Dimethyl-1H-purine, and of the 1-(Azidobenzyl)adenines

A selective synthesis of 1,6-dimethylpurine (16) and the preparations of the 1-(azidobenzyl)adenines (11)-(13), 8-azido-1-benzyladenine (10), and 1-methyladenine derivatives (2)-(9) with various 8-substituents (azido, chloro, bromo, alkyl, and hydroxymeth