92001-53-1

Usage

Properties

1. Chemical formula: C9H8ClN4O
2. Molecular weight: 214.64 g/mol
3. Purine derivative
4. Xanthine analog
5. White to off-white crystalline powder
6. Soluble in dimethyl sulfoxide and dimethyl formamide
7. Sparingly soluble in water and ethanol

Specific content

1. Commonly used in research as a potent adenosine receptor antagonist
2. Used in pharmaceutical and biochemical research
3. Ability to block the action of adenosine receptors
4. Potential applications in the development of therapeutic agents for conditions such as asthma, inflammation, and COPD.

InChI:InChI=1/C7H7ClN4/c1-2-4-11-5-6(8)9-3-10-7(5)12-4/h3,5H,2H2,1H3

Upstream product

• 92001-51-9 4-amino-6-oxo-5-propanoylamino-1,6-dihydropyrimidine 
• 4316-98-7 6-chloro-4,5-diaminopyrimidine 
• 115-80-0 Triethyl orthopropionate 
• 729589-38-2 8-ethyl-9H-purin-6-ol 

Relevant academic research and scientific papers

Design and optimization of purine derivatives as in vivo active PDE10A inhibitors

Phosphodiesterases are important enzymes regulating signal transduction mediated by second messenger molecules cAMP or cGMP. PDE10A is a unique member in the PDE family because of its selective expression in medium spiny neurons. It is recognized as anti-psychotic drug target. Based on the structural similarity between our previous chemistry work on 8-aminoimidazo[1,2-a]pyrazines and the PDE10A inhibitors reported by Bartolome-Nebreda et al., we initialized a project for developing PDE10A inhibitors. After several rounds of optimization, we were able to obtain a few compounds with good PDE10A enzymatic activity. And after further PDE enzymatic selectivity study, metabolic stability assay and in vivo pharmacological tests we identified two inhibitors as interesting lead compounds with the potential for further PDE10A lead optimizatioin.

Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors

The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.

Specificity of the 1-Methyladenine Receptors in Starfish Oocytes: Synthesis and Properties of Some 1,8-Disubstituted Adenines, 1,6-Dimethyl-1H-purine, and of the 1-(Azidobenzyl)adenines

A selective synthesis of 1,6-dimethylpurine (16) and the preparations of the 1-(azidobenzyl)adenines (11)-(13), 8-azido-1-benzyladenine (10), and 1-methyladenine derivatives (2)-(9) with various 8-substituents (azido, chloro, bromo, alkyl, and hydroxymeth