920339-22-6

Upstream product

• 98-01-1 furfural 
• 103-72-0 phenyl isothiocyanate 
• 62-53-3 aniline 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 

Downstream Products

• 1428241-02-4 [(copper(II))2(2-furaldehyde-4-phenylisothiosemicarbazone^(1-))2(triethylamine)2(H₂O)4](SO₄) 
• 133416-79-2 (copper(II))(2-furaldehyde-4-phenylisothiosemicarbazone^(1-))2(H₂O)2 
• 1428241-04-6 (copper(II))(2-furaldehyde-4-phenylisothiosemicarbazone^(1-))(OAc)2(H₂O)2 

Relevant academic research and scientific papers

Synthesis, crystal structures and fluorescence properties of Ni (II) and Cu (II) complexes with 1-(Furan-2-ylmethylene)-4-phenylthiosemicarbazone

Two coordination complexes, NiL2 and CuL2 {L = bis[1-(furan-2-ylmethylene)-4-phenylthiosemicarbazone]}, were synthesized and determined by X-ray crystallography. Both crystallize in the Orthorhombic system, space group Pbcn, with lattice parameters: a = 11.935 (2) A, b = 15.314(3) A, c = 12.952(3) A and Z = 4 for Ni (II); a = 20.850(4) A, b = 15.049(3) A, c = 7.5633(5) A and Z = 4 for Cu (II). In both complexes, the central metal atom is coordinated in a distorted square-planar with two ligands through two S and N atoms, respectively. The EA, UV, IR and TG-DTG were studied and the possible structures of the complexes were speculated. Moreover, the fluorescence of the complexes were studied. The results reveal that copper complex can emit purple fluorescence in solvents.

Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents

In this paper, a series of thiosemicarbazone derivatives containing different aromatic heterocyclic groups were synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds showed improved antiproliferative activity against MGC803 cells. SAR studies revealed that compound 5d displayed significant advantages in inhibition effect with an IC50 value of 0.031 μM, and better selectivity between cancer and normal cells than 3-AP and DpC (about 15- and 5-fold improved respectively). Besides, compound 5d showed selective antiproliferative activity in not only other cancer cells but also different gastric cancer cell lines. In-depth mechanism studies showed that compound 5d could induce mitochondria-related apoptosis which might be related to the elevation of intracellular ROS level, and cause cell cycle arrest at S phase. Moreover, 5d could evidently suppress the cell migration and invasion by blocking the EMT (epithelial–mesenchymal transition) process. Consequently, our studies provided a lead optimization strategy of thiosemicarbazone derivatives which would contribute to discover high-efficiency and low-toxicity agents for the treatment of gastric cancer.

Synthesis, characterization and crystal structures of nickel(II), palladium(II) and copper(II) complexes with 2-furaldehyde-4- phenylthiosemicarbazone

2-Furaldehyde-4-phenylthiosemicarbazone (HL) and its nickel(II), palladium(II) and copper(II) complexes: [Pd(L)2] (1), [Ni(L) 2] (2), [Cu2(L)2(Et3N) 2(H2O)4 ](SO4