920509-48-4Relevant articles and documents
THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS
-
, (2020/03/09)
Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by THR beta.
Selective thyroid hormone receptor β agonists with oxadiazolone acid isosteres
Kirschberg, Thorsten A.,Jones, Christopher T.,Xu, Yingzi,Fenaux, Martijn,Halcomb, Randall L.,Wang, Yujin,Klucher, Kevin
supporting information, (2020/09/01)
Use of the oxadiazolone acid isostere in triiodothyronine analogs yielded potent and selective agonists for the thyroid hormone receptor β. Selected examples showed good in-vivo efficacy in a rat hypercholesterolemic model. One compound was further profiled in a diet-induced mouse model of nonalcoholic steatohepatitis (NASH) and showed robust target engagement and significant histological improvements in both liver steatosis and fibrosis.
PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS
-
Page/Page column 102, (2008/06/13)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.