920748-45-4Relevant academic research and scientific papers
Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers
Lloyd, John,Finlay, Heather J.,Vacarro, Wayne,Hyunh, Tram,Kover, Alexander,Bhandaru, Rao,Yan, Lin,Atwal, Karnail,Conder, Mary Lee,Jenkins-West, Tonya,Shi, Hong,Huang, Christine,Li, Danshi,Sun, Huabin,Levesque, Paul
scheme or table, p. 1436 - 1439 (2010/07/02)
Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.
PEPTIDE DEFORMYLASE INHIBITORS
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Page/Page column 25, (2010/11/27)
Novel PDF inhibitors of formulas (I) and (II), pharmaceutical compositions thereof and methods for their use in the treatment of bacterial infections are described.
PREPARATION OF TERAZOLE DERIVATIVES
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Page/Page column 31-32, (2010/11/25)
The invention relates to a process for the preparation of (S)-pyrrolidine-1H-tetrazole derivatives of formula (I), wherein R1, R2 and R3, independently of one another, represent hydrogen, halogen or an organic radical, in
