DIPHTHERIA TOXIN is a potent bacterial toxin produced by Corynebacterium diphtheriae, a Gram-positive bacterium responsible for diphtheria, a severe respiratory infection. It is composed of two polypeptide chains, an enzymatically active A chain and a B chain that facilitates cell binding and entry. The A chain acts as an NAD:EF2 ADP-ribosyltransferase, inhibiting protein synthesis and leading to cell death. DIPHTHERIA TOXIN has been extensively studied for its potential applications in medicine and biotechnology.
92092-36-9
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Basic information
- Product Name: DIPHTHERIA TOXIN
- Synonyms: DIPHTHERIA TOXIN;DIPHTHERIA TOXIN, CRM MUTANT;DIPHTHERIA TOXIN, UNNICKED, CORYNEBACTERIUM DIPHTHERIAE;CORYNEBACTERIUM DIPHTHERIAE TOXIN;(glu52)-diphtheria toxin from*corynebacterium dip;(GLU-52)-DIPHTHERIA TOXIN FROM*CORYNEBAC;[glu52]-diphtheria toxin from corynebacterium diphtheriae;Diphtheria toxin[Glu-52], Corynebacterium diphtheriae
- CAS NO:92092-36-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: RNA-Protein Translation Inhibitors;Toxins and Venoms;BacteriaCell Signaling and Neuroscience;Cell Signaling and Neuroscience;Gene Regulation and Expression
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /lyophilized powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- CAS DataBase Reference: DIPHTHERIA TOXIN(CAS DataBase Reference)
- NIST Chemistry Reference: DIPHTHERIA TOXIN(92092-36-9)
- EPA Substance Registry System: DIPHTHERIA TOXIN(92092-36-9)
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Safety Data
- Hazard Codes: T+
- Statements: 28
- Safety Statements: 22-24/25-45-36/37-28
- RIDADR: 3172
- WGK Germany: 3
- RTECS: XW5807200
- HazardClass: 6.1(a)
- PackingGroup: I
- Hazardous Substances Data: 92092-36-9(Hazardous Substances Data)
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92092-36-9 Usage
Uses
Used in Immunotoxin Development:DIPHTHERIA TOXIN is used as a toxin element in the construction of immunotoxins for cell-specific cytotoxicity. These immunotoxins are engineered to target specific cells, such as cancer cells or immune cells, by conjugating the toxin with a targeting moiety, like an antibody or a ligand. This allows for the selective delivery of the toxin to the target cells, inducing cell death and providing a potential therapeutic approach for various diseases.
Used in Gene Therapy:
The translocation domain of DIPHTHERIA TOXIN, which possesses a natural endosome escape mechanism, has been utilized in the development of efficient nonviral vectors for gene therapy applications. By incorporating this domain into gene delivery systems, researchers aim to improve the cellular uptake and intracellular trafficking of therapeutic genes, enhancing the overall efficiency of gene therapy.
Used in CRM Mutant Development:
DIPHTHERIA TOXIN, CRM Mutant, is an engineered version of the toxin that lacks NAD:EF2 ADP-ribosyltransferase activity. This modification renders the CRM Mutant non-toxic, while retaining its ability to bind to target cells. The CRM Mutant has been used as a carrier protein in vaccine development, particularly for the production of vaccines against diphtheria. By conjugating the CRM Mutant with antigens from other pathogens, researchers can develop multivalent vaccines that provide protection against multiple diseases.
Biochem/physiol Actions
Inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II.Check Digit Verification of cas no
The CAS Registry Mumber 92092-36-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,0,9 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.Calculate Digit Verification of CAS Registry Number 92092-36:
(7*9)+(6*2)+(5*0)+(4*9)+(3*2)+(2*3)+(1*6)=129
129 % 10 = 9
So 92092-36-9 is a valid CAS Registry Number.
92092-36-9Upstream product
92092-36-9Downstream Products
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DIPHTHERIA TOXIN
