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3-Amino-2-iodo-6-(trifluoromethyl)-pyridine is a pyridine derivative with a molecular formula C6H4F3IN2. It features an amino group, an iodine atom, and a trifluoromethyl group, which contribute to its versatile reactivity and unique structural properties. This chemical compound is often utilized in organic synthesis and pharmaceutical research due to its potential in the development of heterocyclic compounds and functional materials. The presence of the trifluoromethyl group also makes it a valuable component in drug design and discovery, as fluorine substitutions can improve the physicochemical properties and pharmacological activities of bioactive molecules. However, it is crucial to handle this compound with care due to its potential hazards if not properly managed.

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  • 920979-04-0 Structure
  • Basic information

    1. Product Name: 3-Amino-2-iodo-6-(trifluoromethyl)-pyridine
    2. Synonyms: 3-Amino-2-iodo-6-(trifluoromethyl)-pyridine;3-Amino-6-iodo-2-trifluoromethylpyridine;5-Amino-6-iodo-2-(trifluoromethyl)pyridine
    3. CAS NO:920979-04-0
    4. Molecular Formula: C6H4F3IN2
    5. Molecular Weight: 288.01
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 920979-04-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 233.1°C at 760 mmHg
    3. Flash Point: 94.8°C
    4. Appearance: /
    5. Density: 1.892g/cm3
    6. Vapor Pressure: 0.0867mmHg at 25°C
    7. Refractive Index: 1.586
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    9. Solubility: N/A
    10. CAS DataBase Reference: 3-Amino-2-iodo-6-(trifluoromethyl)-pyridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-Amino-2-iodo-6-(trifluoromethyl)-pyridine(920979-04-0)
    12. EPA Substance Registry System: 3-Amino-2-iodo-6-(trifluoromethyl)-pyridine(920979-04-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 920979-04-0(Hazardous Substances Data)

920979-04-0 Usage

Uses

Used in Organic Synthesis:
3-Amino-2-iodo-6-(trifluoromethyl)-pyridine is used as a building block in organic synthesis for the creation of various heterocyclic compounds and functional materials. Its unique structural features and reactivity make it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Amino-2-iodo-6-(trifluoromethyl)-pyridine is used as a key intermediate in drug design and discovery. Its trifluoromethyl group is particularly advantageous, as fluorine substitutions are known to enhance the stability, solubility, and overall pharmacological profile of drug candidates, potentially leading to improved therapeutic efficacy and safety.
Used in Drug Design and Discovery:
3-Amino-2-iodo-6-(trifluoromethyl)-pyridine is employed as a structural moiety in drug design and discovery, where its unique combination of functional groups can be leveraged to create novel bioactive molecules with enhanced properties. The presence of the trifluoromethyl group can significantly impact the physicochemical and pharmacological characteristics of the resulting compounds, making it a promising candidate for the development of new therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 920979-04-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,0,9,7 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 920979-04:
(8*9)+(7*2)+(6*0)+(5*9)+(4*7)+(3*9)+(2*0)+(1*4)=190
190 % 10 = 0
So 920979-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H5FIN/c1-4-2-3-5(8)6(7)9-4/h2-3H,1H3

920979-04-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Iodo-6-(trifluoromethyl)pyridin-3-amine

1.2 Other means of identification

Product number -
Other names 2-iodo-6-(trifluoromethyl)pyridin-3-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:920979-04-0 SDS

920979-04-0Relevant articles and documents

ISOINDOLINES AS HDAC INHIBITORS

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Paragraph 00223, (2019/11/12)

The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs), having the formula: (I) wherein Z, X1, X2, Y1, Y2, Y3, L, Z, and R are described herein.

1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

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Paragraph 01107; 01108; 01109, (2016/09/22)

The invention is concerned with the compounds of formula I and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

N-(amino-heteroaryl)-1H-pyrrolopyridine-2-carboxamides derivatives preparation thereof and their use in therapy

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Page/Page column 19-20, (2010/03/04)

The invention relates to compounds of the general formula (I): Wherein X, Y, Z, Z1, Z2, Z3, Z4 and n are as defined herein. The invention also relates to a method for making the same and to the use thereof in th

INHIBITORS OF JUN N-TERMINAL KINASE

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Page/Page column 142, (2010/08/18)

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

TRICYCLIC N-HETEROARYL-CARBOXAMIDE DERIVATIVES CONTAINING A BENZIMIDAZOLE UNIT, METHOD FOR PREPARING SAME AND THEIR THERAPEUTIC USE

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Page/Page column 25, (2009/03/07)

The invention concerns tricyclic N-heteroarylcarboxamide derivatives containing a benzimidazole unit of general formula (I): Wherein A, P, Y, R1, R2 and R3 are as defined herein. The invention also concerns a method of preparing the compounds and their therapeutic use.

Pyrrolopyridine Compounds, Method of Making Them and Uses Thereof

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Page/Page column 6, (2008/12/08)

Pyrrolopyridine compounds corresponding to formula (I): as defined in the claims, pharmaceutically acceptable salts thereof, the process for preparing such compounds, pharmaceutical compositions containing such compounds, and their use as pharmacologicall

N-(ARYLALKYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF

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Page/Page column 16, (2008/12/05)

The invention concerns compounds of general formula (I), wherein n, the pyrrolopyridine ring, X, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. The invention also concerns a method for preparing said compounds and their therapeutic use.

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