921-74-4

Basic information

• Product Name: ethyl L-isoleucinate
• Synonyms: ethyl L-isoleucinate;Isoleucine ethyl ester;L-Isoleucine ethyl ester
• CAS NO: 921-74-4
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.22608
• EINECS: 213-070-4
• Mol File: 921-74-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 191.4°C at 760 mmHg
• Flash Point: 62.9°C
• Appearance: /
• Density: 0.944g/cm³
• Vapor Pressure: 0.515mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: ethyl L-isoleucinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl L-isoleucinate(921-74-4)
• EPA Substance Registry System: ethyl L-isoleucinate(921-74-4)

Safety Data

• Hazardous Substances Data: 921-74-4(Hazardous Substances Data)

Usage

General Description

Ethyl L-isoleucinate is a chemical compound with the molecular formula C8H17NO2. It is a derivative of the amino acid isoleucine, containing an ethyl group attached to the L-isoleucine molecule. ethyl L-isoleucinate is used in the food and beverage industry as a flavoring agent and aroma compound due to its fruity, ethereal, and sweet odor. It can also be used in the formulation of perfumes and cosmetic products. Ethyl L-isoleucinate is generally recognized as safe (GRAS) for use as a food additive, and it is considered to have low toxicity. However, it should be handled and used with care in accordance with relevant safety guidelines and regulations.

InChI:InChI=1/C8H17NO2/c1-4-6(3)7(9)8(10)11-5-2/h6-7H,4-5,9H2,1-3H3/t6-,7-/m0/s1

Upstream product

• 64-17-5 ethanol 
• 319-78-8 isoleucine 
• 73-32-5 L-isoleucine 
• 3154-47-0 N-formyl-isoleucine ethyl ester 
• 7732-18-5 water 

Downstream Products

• 911672-00-9 N-(N-benzoyl-glycyl)-L-isoleucine ethyl ester 
• 10512-89-7 (2S,3S)-3-methylproline 
• 1552274-38-0 (2S,3S)-3-methyl-2-(4-phenylimidazol-1-yl)pentanoic acid ethyl ester 
• 926309-00-4 ethyl (chloro(phenoxy)phosphoryl)-L-isoleucinate 
• 817554-69-1 L-(2S,3S)-methylproline ethyl ester 
• 61299-07-8 C₁₅H₂₀N₂O₅S 
• 34603-92-4 3-methyl-2-(2-phenyl-thiazolidin-3-yl)-pentanoic acid ethyl ester 
• 82636-92-8 PChd-L-Ile-Leu-Leu-Ala-OMe 
• 82636-89-3 PChd-L-Ile-Leu-OMe 
• 82636-90-6 PChd-L-Ile-Leu-OH 
• 82636-84-8 PChd-L-Ile-OH 
• 610-88-8 tenuazonic acid 

Relevant articles and documents

Stereospecific Synthesis of 3,4-Dihydro-2 H-naphtho-1,4-oxazin-2-ones by Unification of Benzoxepine-4-carboxylates with Chiral Amino Acid Ethyl Esters

A novel and efficient stereocontrolled method has been developed for the preparation of chiral 3,4-dihydro-2H-naphtho[1,2-b][1,4]oxazin-2-ones by the reaction of benzoxepine-4-carboxylates with chiral amino acid ethyl esters for the first time. The chiral 3,4-dihydro-2H-naphtho-1,4-oxazinones have been achieved in one step by the formation of C-N, C-C, and C-O bonds.

Synthetic studies toward paraherquamides E and F and related 13C-labeled putative biosynthetic intermediates: stereocontrolled synthesis of the α-alkyl-β-methylproline ring system

A substituted 2R-allyl-3S-methylproline ethyl ester suitable for elaboration to paraherquamides E, F and related 13C-labeled putative biosynthesis intermediates have been prepared efficiently in six steps and?24% overall yield. The key steps are a 5-exo-trig cyclization of a zinc enolate on an unactivated alkene and a stereocontrolled alkylation of the enolate formed from 3S-methyl-pyrrolidine-1,2R-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester.

Synthesis of tert-Leucine and Related Amino Acids

The 2,5-dialkoxypyrazines 3a and b were prepared in three steps from methyl glycinate hydrochloride (1) in an overall yield of 18 and 63 percent.Upon the addition of lithium organyls to 3b and subsequent acid hydrolysis the ethyl glycinates rac-7 were obtained.Key Words: tert-Leucine / Amino acids / Glycine cation equivalents / Bislactim ether method