921201-40-3

Upstream product

• 100906-42-1 2-O-benzyl-3,4-O-isopropylidene-L-threose 
• 921201-39-0 tert-butyl (S)-1-(ethoxycarbonyl)-3-(benzyloxy)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-enyl carbamate 

Downstream Products

• 921201-43-6 tert-butyl-(1S,3S,4S)-1-(ethoxycarbonyl)-3-(benzyloxy)-4-hydroxy-5-(tert-butyl dimethyl silyloxy)-pentyl carbamate 
• 921201-45-8 (2S,4S,5R)-ethyl-4-(benzyloxy)-5-(tert-butyl dimethyl silyloxy methyl)pyrrolidine-2-carboxylate 
• 921201-41-4 tert-butyl-(1S,3S,4S)-1-(ethoxycarbonyl)-3-(benzyloxy)-4,5-dihydroxy pentyl carbamate 

Relevant academic research and scientific papers

Stereoselective synthesis of (-)-bulgecinine hydrochloride and its C-2 epimer from l-ascorbic acid

An efficient strategy for the stereocontrolled synthesis of (-)-bulgecinine hydrochloride 1 was accomplished by utilizing a Wittig Horner olefination, stereoselective reduction of the double bond and intramolecular N-alkylation to furnish the target.