92133-31-8Relevant academic research and scientific papers
Hypocholesterolemic activity of some novel azetidin-2-ones in diet and diabetes induced hypercholesterolemia in rats
Goel,Thind,Bal,Mahajan,Kulkarni
, p. 369 - 374 (2007/10/03)
Some novel substituted azetidin-2-ones (5-8) were synthesized via {2 + 2} cycloaddition reactions of imines and ketenes and evaluated for their ability to prevent diet and diabetes induced hypercholesterolemia. The test compounds 5a and 7a significantly (p a dose dependent manner. Compound 5a also raised the high density lipoprotein-cholesterol levels in chronic diet models by peanut oil (5.5%), cholesterol (1.5%) and cholic acid (0.5%). In a diabetes induced model of hypercholesterolemia, the test compounds were evaluated for preventing diabetes-induced hypercholesterolemia (protocol 1) as well as for lowering post diabetic hypercholesterolemia (protocol 2). Test compounds 5a-g and 7a-d significantly (p a greater reduction in protocol 1 as compared with protocol 2. Based on SAR studies, the substituents that favor hypocholesterolemic activity around the azetidin-2-one nucleus are discussed and a possible mechanism of action is proposed on the basis of their differential effects in two protocols of diabetes-induced hypercholesterolemia.
SYNTHESIS OF β-LACTAMS BY CONVENIENT ANNELATION OF IMINES
Miyake, M.,Tokutake, N.,Kirisawa, M.
, p. 353 - 362 (2007/10/02)
2-Acyl-3-oxo-4,5-benzo-1,2-thiazoline 1,1-dioxide (3) provides good yield routes to monocyclic β-lactams (6) and tricycic β-lactams (7) from a variety of imines (4) and 1-substituted-3,4-dihydroisoquinolines (5).
