92144-28-0 Usage
Uses
Used in Pharmaceutical Industry:
2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide is used as a potential therapeutic agent for its potential antibacterial properties, given the historical use of sulfonamides in this context. 2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide's structure may allow it to interfere with bacterial metabolic processes, thereby inhibiting bacterial growth.
Used in Anticancer Research:
In the field of oncology, 2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide is being investigated for its potential as an anticancer agent. 2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide's structure may enable it to interact with cellular targets, such as enzymes or receptors, that are critical for cancer cell survival and proliferation, thus offering a new avenue for cancer treatment.
Used in Antiviral Applications:
2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide is also being explored for its potential antiviral activity. Given the structural similarities to other sulfonamides, it may have the ability to inhibit viral replication or interfere with viral entry into host cells, making it a candidate for the development of new antiviral drugs.
Used in Diuretic Formulations:
As a derivative of sulfonamides, which are known for their diuretic effects, 2,4-diamino-N-(3,4-dichlorophenyl)quinazoline-6-sulfonamide may be used as a component in diuretic formulations. Its potential use in this area would be to aid in the treatment of conditions that require increased urine output, such as edema or high blood pressure.
Check Digit Verification of cas no
The CAS Registry Mumber 92144-28-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,4 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 92144-28:
(7*9)+(6*2)+(5*1)+(4*4)+(3*4)+(2*2)+(1*8)=120
120 % 10 = 0
So 92144-28-0 is a valid CAS Registry Number.
92144-28-0Relevant academic research and scientific papers
Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides
Elslager,Colbry,Davoll,Hutt,Johnson,Werbel
, p. 1740 - 1743 (2007/10/02)
The synthesis and antimalarial activity of a series of 2,4-diamino-6-quinazolinesulfonamides is described. Chlorosulfonation of 2,4-quinazolinediamine affords the 6-sulfonyl chloride, which upon treatment with the appropriate amine produces the desired products. Alternatively the sulfonyl chloride could be introduced by diazotization of the corresponding amine followed by treatment with SO2 in the presence of CuCl2. Although substantial antimalarial activity was demonstrated for several members of this class, studies were discontinued in light of the potency of related series.
