92144-29-1 Usage
Uses
Used in Oncology:
2,4-diamino-N-(3-chlorophenyl)-N-methylquinazoline-6-sulfonamide is used as an antineoplastic agent for its potential to inhibit the enzyme dihydrofolate reductase, thereby preventing the growth of cancer cells. This makes it a candidate for the treatment of certain types of cancer.
Used in Pharmaceutical Research:
2,4-diamino-N-(3-chlorophenyl)-N-methylquinazoline-6-sulfonamide is used as a subject of research in the pharmaceutical industry to explore its potential biological activities and applications in medicine. Further studies are needed to fully understand its capabilities and optimize its use in various medical settings.
Used in Drug Development:
In the field of drug development, 2,4-diamino-N-(3-chlorophenyl)-N-methylquinazoline-6-sulfonamide is utilized as a lead compound for the design and synthesis of new antineoplastic drugs. Its unique structure and mechanism of action offer opportunities for the development of novel therapeutic agents targeting cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 92144-29-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,4 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 92144-29:
(7*9)+(6*2)+(5*1)+(4*4)+(3*4)+(2*2)+(1*9)=121
121 % 10 = 1
So 92144-29-1 is a valid CAS Registry Number.
92144-29-1Relevant academic research and scientific papers
Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides
Elslager,Colbry,Davoll,Hutt,Johnson,Werbel
, p. 1740 - 1743 (2007/10/02)
The synthesis and antimalarial activity of a series of 2,4-diamino-6-quinazolinesulfonamides is described. Chlorosulfonation of 2,4-quinazolinediamine affords the 6-sulfonyl chloride, which upon treatment with the appropriate amine produces the desired products. Alternatively the sulfonyl chloride could be introduced by diazotization of the corresponding amine followed by treatment with SO2 in the presence of CuCl2. Although substantial antimalarial activity was demonstrated for several members of this class, studies were discontinued in light of the potency of related series.
