92144-31-5 Usage
Uses
Used in Pharmaceutical Industry:
2,4-diamino-N-(3,4-dichlorobenzyl)-N-methylquinazoline-6-sulfonamide is used as a potential therapeutic agent for the treatment of various medical conditions due to its potential inhibitory effect on carbonic anhydrase.
Used in Ophthalmology:
2,4-diamino-N-(3,4-dichlorobenzyl)-N-methylquinazoline-6-sulfonamide is used as a potential treatment for glaucoma, a condition characterized by increased intraocular pressure, as its carbonic anhydrase inhibitory activity may help in reducing this pressure.
Used in Neurology:
2,4-diamino-N-(3,4-dichlorobenzyl)-N-methylquinazoline-6-sulfonamide is used as a potential treatment for epilepsy, a neurological disorder characterized by recurrent seizures, as its inhibitory effect on carbonic anhydrase may help in controlling the disorder.
Used in Oncology:
2,4-diamino-N-(3,4-dichlorobenzyl)-N-methylquinazoline-6-sulfonamide is used as a potential anticancer agent for the treatment of certain types of cancer, as its inhibitory effect on carbonic anhydrase may interfere with the tumor's acid-base balance and respiration, thereby inhibiting tumor growth and progression.
Check Digit Verification of cas no
The CAS Registry Mumber 92144-31-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,4 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 92144-31:
(7*9)+(6*2)+(5*1)+(4*4)+(3*4)+(2*3)+(1*1)=115
115 % 10 = 5
So 92144-31-5 is a valid CAS Registry Number.
92144-31-5Relevant academic research and scientific papers
Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides
Elslager,Colbry,Davoll,Hutt,Johnson,Werbel
, p. 1740 - 1743 (2007/10/02)
The synthesis and antimalarial activity of a series of 2,4-diamino-6-quinazolinesulfonamides is described. Chlorosulfonation of 2,4-quinazolinediamine affords the 6-sulfonyl chloride, which upon treatment with the appropriate amine produces the desired products. Alternatively the sulfonyl chloride could be introduced by diazotization of the corresponding amine followed by treatment with SO2 in the presence of CuCl2. Although substantial antimalarial activity was demonstrated for several members of this class, studies were discontinued in light of the potency of related series.
