92154-91-1Relevant academic research and scientific papers
Titanium-mediated alkylative cyclizations of 1,3-diene-tethered esters
Quan, Long Guo,Cha, Jin Kun
, p. 2745 - 2747 (2007/10/03)
(Equation presented) An alkylative titanium-mediated cyclization reaction of 1,3-diene-tethered carboxylic esters has been developed by employing an in situ generated titanacyclopropane intermediate to afford trans-2-alkenyl cyclohexanols.
Diastereoselective synthesis of polysubstituted tetrahydropyrans and thiacyclohexanes via indium trichloride mediated cyclizations
Yang,Mague,Li
, p. 739 - 747 (2007/10/03)
Polysubstituted tetrahydropyrans and thiacyclohexanes were synthesized in high yields with excellent diastereoselectivities via indium trichloride mediated cyclizations between homoallyl alcohols and mercaptans with aldehydes. In the case of tetrahydropyran products, the stereochemistry of the product was found to be directly correlated with the geometry of the homoallyl alcohols; whereas the cross-cyclization of aldehydes with trans-homoallyl alcohols generated (up-down-up) 2,3,4-trisubstituted tetrahydropyran products exclusively, the reaction of aldehydes with cis-homoallyl alcohols provided mainly (up-up-up) 2,3,4-trisubstituted products. When a trisubstituted homoallyl alcohol was used, its cross-cyclization with aldehydes generated (up-down-up-down-up) pentasubstituted tetrahydropyran derivatives with simultaneous controlling of five stereogenic centers. On the other hand, a cyclization-decyclization equilibrium was observed in the formation of thiacyclohexanes. The reaction of both cis- and trans-homoallyl mercaptans with aldehydes provided the same major diastereomers.
BORON TRIFLUORIDE ASSISTED OPENING OF EPOXIDES BY LITHIUM ALKENYL ALUMINATE REAGENTS
Alexakis, A.,Jachiet, D.
, p. 6197 - 6202 (2007/10/02)
Alkenyl aluminate reagents, obtained by hydroalumination of terminal alkynes followed by ate complexation with MeLi, react readily with poorly reactive cyclic ethers such as cyclohexene oxide and oxetane, in the presence of BF3*Et2O.Alkenyl aluminate reag
