92155-94-7Relevant academic research and scientific papers
The efficient synthesis of (3R,4R,5R)-3-amino-4,5-dimethyl-octanoic acid, a chiral β-amino acid with potent affinity for the α2δ protein
Zhang, Ji,Blazecka, Peter G.,Pflum, Derek A.,Bozelak, Joseph,Vrieze, Derek,Colbry, Norman L.,Hoge, Garrett,Boyles, David C.,Samas, Brian,Curran, Timothy T.,Osuma, Augustine T.,Johnson, Paul,Kesten, Suzanne,Schwarz, Jacob B.,Goodman, Annise,Plummer, Mark,Akin, Anne,Huang, Yun,Lovdahl, Michael,Thorpe, Andrew J.
supporting information; experimental part, p. 1167 - 1170 (2009/06/28)
A chiral β-amino acid containing three contiguous chiral centers was synthesized efficiently in 11 steps, employing enantio-enriched β-ketoester as a key intermediate, via stereoselective catalytic hydrogenation of the corresponding enamide. Stereoselecti
