921599-79-3 Usage
Molecular structure
The compound has a triaza ring and a spiro ring system.
Chirality
It is a chiral molecule with a (5R,7S) configuration.
Class
It belongs to the class of spiroketals.
Application
It can be used in medicinal chemistry for drug discovery and development.
Unique structure
Its unique structure and properties make it a valuable building block for the synthesis of various pharmaceutical compounds.
Potential therapeutic benefits
It has potential therapeutic benefits and may lead to the discovery of new drugs and treatments for various medical conditions.
Further research
Further research and study on this compound may lead to the discovery of new drugs and treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 921599-79-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,1,5,9 and 9 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 921599-79:
(8*9)+(7*2)+(6*1)+(5*5)+(4*9)+(3*9)+(2*7)+(1*9)=203
203 % 10 = 3
So 921599-79-3 is a valid CAS Registry Number.
921599-79-3Relevant articles and documents
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency
Egbertson, Melissa,McGaughey, Georgia B.,Pitzenberger, Steven M.,Stauffer, Shaun R.,Coburn, Craig A.,Stachel, Shawn J.,Yang, Wenjin,Barrow, James C.,Neilson, Lou Anne,McWherter, Melody,Perlow, Debra,Fahr, Bruce,Munshi, Sanjeev,Allison, Timothy J.,Holloway, Katharine,Selnick, Harold G.,Yang, Zhiqiang,Swestock, John,Simon, Adam J.,Sankaranarayanan, Sethu,Colussi, Dennis,Tugusheva, Katherine,Lai, Ming-Tain,Pietrak, Beth,Haugabook, Shari,Jin, Lixia,Chen,Holahan, Marie,Stranieri-Michener, Maria,Cook, Jacquelynn J.,Vacca, Joseph,Graham, Samuel L.
, p. 4812 - 4819 (2015/10/28)
The IC50 of a beta-secretase (BACE-1) lead compound was improved ～200-fold from 11 μM to 55 nM through the addition of a single methyl group. Computational chemistry, small molecule NMR, and protein crystallography capabilities were used to com
