921604-32-2Relevant academic research and scientific papers
4-Aminopyrimidines as novel HIV-1 inhibitors
Gadhachanda, Venkat R.,Wu, Baogen,Wang, Zhiwei,Kuhen, Kelli L.,Caldwell, Jeremy,Zondler, Helmut,Walter, Harald,Havenhand, Mark,He, Yun
, p. 260 - 265 (2007/10/03)
A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.
