92161-72-3Relevant academic research and scientific papers
Recyclable Cellulose-Derived Fe3O4@Pd NPs for Highly Selective C–S Formation by Heterogeneously C–H Sulfenylation of Indoles
Li, Shengyi,Wang, Jinguo,Jin, Jianzhong,Tong, Jianying,Shen, Chao
, p. 2409 - 2414 (2020/02/25)
Abstract: An efficient and convenient method was developed for the preparation of 3-sulfenylindoles via a cellulose-derived Fe3O4@Pd NPs catalyzed heterogeneously C–H sulfenylation of indoles. This approach provides an effective synthetic route to an important class of indoles derivatives and features high efficiency, easy operation, good practicality, and environmental friendliness. The recoverable catalyst was separated from the reaction mixture using an outside magnetic field and can be recycled five times without huge loss of catalytic performance. Graphic Abstract: An efficient method was developed for the preparation of 3-sulfenylindoles via cellulose-derived Fe3O4@Pd NPs catalyzed heterogeneously C–H sulfenylation of indoles.[Figure not available: see fulltext.].
Palladium-Catalyzed Oxidative Sulfenylation of Indoles and Related Electron-Rich Heteroarenes with Aryl Boronic Acids and Elemental Sulfur
Li, Jianxiao,Li, Chunsheng,Yang, Shaorong,An, Yanni,Wu, Wanqing,Jiang, Huanfeng
, p. 7771 - 7783 (2016/09/12)
An efficient and convenient palladium-catalyzed C-H bond oxidative sulfenylation of indoles and related electron-rich heteroarenes with aryl boronic acids and elemental sulfur has been described. This procedure provides a useful and direct approach for the assembly of a wide range of structurally diverse 3-sulfenylheteroarenes with moderate to excellent yields from simple and readily available starting materials. Moreover, this synthetic protocol is suitable for N-protected and unprotected indoles. Notably, the construction of two C-S bonds in one step was also achieved in this transformation.
Byproduct promoted regioselective sulfenylation of indoles with sulfinic acids
Liu, Cong-Rong,Ding, Liang-Hui
supporting information, p. 2251 - 2254 (2015/03/04)
An unprecedented method to synthesise 3-sulfenylindoles is demonstrated via byproduct promoted sulfenylation of indoles with sulfinic acids in the absence of an external catalyst. The reaction selectively afforded structurally diverse indole thioethers in good to excellent yields in 1,2-dichloroethane at 80 °C. This journal is
Iodine-catalyzed regioselective sulfenylation of indoles with sodium sulfinates
Xiao, Fuhong,Xie, Hao,Liu, Saiwen,Deng, Guo-Jun
supporting information, p. 364 - 368 (2014/05/20)
An iodine-catalyzed sulfenylation of free indoles with sodium sulfinates is described. The reaction selectively afforded 3-arylthioindoles in good to high yields in anisole under metal-free conditions. Functional groups such as halogens were well tolerated under the optimized reaction conditions.
Iodine-catalyzed regioselective sulfenylation of indoles with sulfonyl hydrazides
Yang, Fu-Lai,Tian, Shi-Kai
supporting information, p. 4929 - 4932 (2013/06/04)
New S in town: Sulfonyl hydrazides smoothly undergo sulfenylation with indoles in the presence of 10 mol % I2 to give structurally diverse indole thioethers in moderate to excellent yields with extremely high regioselectivity. This study paves the way for the use of sulfonyl hydrazides as unique sulfur electrophiles in chemical synthesis. Copyright
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands
Bernotas, Ronald,Lenicek, Steven,Antane, Schuyler,Zhang, Guo Ming,Smith, Deborah,Coupet, Joseph,Harrison, Boyd,Schechter, Lee E.
, p. 5499 - 5502 (2007/10/03)
Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively. Novel 1-(2-aminoethyl)-3-(arylsulfonyl)-1H-indoles were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which N,N-dimethyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8t and N-methyl-N-{2-[3-(1-naphthylsulfonyl)-1H-indol-1-yl]ethyl}amine 8u showed high affinity for 5-HT6 receptors with Ki = 3.7 and 5.7 nM, respectively.
