921616-45-7Relevant academic research and scientific papers
4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists
Procopiou, Panayiotis A.,Ancliff, Rachael A.,Bamford, Mark J.,Browning, Christopher,Connor, Helen,Davies, Susannah,Fogden, Yvonne C.,Hodgson, Simon T.,Holmes, Duncan S.,Looker, Brian E.,Morriss, Karen M. L.,Parr, Christopher A.,Pickup, Elizabeth A.,Sehmi, Sanjeet S.,White, Gemma V.,Watts, Clarissa J.,Wilson, David M.,Woodrow, Michael D.
, p. 6706 - 6717 (2008/09/17)
A series of ketopiperazines were prepared and evaluated for their activity as histamine H3 antagonists. From investigation of the tertiary basic center in the aminopropyloxyphenyl template, the 2(R)-methylpyrrolidine was identified as the most
