921616-59-3Relevant academic research and scientific papers
4-Acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists
Procopiou, Panayiotis A.,Ancliff, Rachael A.,Bamford, Mark J.,Browning, Christopher,Connor, Helen,Davies, Susannah,Fogden, Yvonne C.,Hodgson, Simon T.,Holmes, Duncan S.,Looker, Brian E.,Morriss, Karen M. L.,Parr, Christopher A.,Pickup, Elizabeth A.,Sehmi, Sanjeet S.,White, Gemma V.,Watts, Clarissa J.,Wilson, David M.,Woodrow, Michael D.
, p. 6706 - 6717 (2007)
A series of ketopiperazines were prepared and evaluated for their activity as histamine H3 antagonists. From investigation of the tertiary basic center in the aminopropyloxyphenyl template, the 2(R)-methylpyrrolidine was identified as the most
PIPERAZINONE DERIVATIVES USEFUL AS HISTAMINE H3 RECEPTOR ANTAGONISTS AND/OR INVERSE AGONISTS
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Page/Page column 32-33; 10-11, (2010/11/25)
The invention relates to compounds of formula (I) or salts and solvates thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis, wherein R1 and
