921617-76-7

Basic information

• Product Name: Benzenesulfonic acid, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
• CAS NO: 921617-76-7
• Molecular Formula: C17H13F3N2O3S
• Molecular Weight: 382.363
• Mol File: 921617-76-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenesulfonic acid, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonic acid, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-(921617-76-7)
• EPA Substance Registry System: Benzenesulfonic acid, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-(921617-76-7)

Safety Data

• Hazardous Substances Data: 921617-76-7(Hazardous Substances Data)

Upstream product

• 720-94-5 4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione 
• 122-00-9 para-methylacetophenone 
• 169590-42-5 4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide 
• 98-71-5 4-hydrazino-benzenesulfonic acid 

Downstream Products

• 190711-56-9 4-[5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazol-1-yl]benzenesulfonyl chloride 

Relevant articles and documents

Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light

Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.

Preparation method of celecoxib genotoxic impurity

The invention provides a preparation method of a celecoxib genotoxic impurity. The method comprises the following steps: step 1, cyclizing G1 and G2 to generate G3; step 2, carrying out sulfonylationon the G3 to obtain G4; 3, generating G5 by the G4, name

New celecoxib derivatives as anti-inflammatory agents

A series of 1,5-diarylpyrazoles with a substituted benzenesulfonamide moiety was synthesized and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Some compounds, for example, (±)-2-[4-(5-p-tolyl-3- trifluoromethyl-pyrazole-1-yl)-benzenesulfonylaminooxy]-propionic acid 16 and its disodium salt 21, had a higher in vivo anti-inflammatory activity compared to celecoxib, despite having no in vitro COX-1 or COX-2 inhibitory activity. Their gastrointestinal side effect profile is essentially more favorable than that of celecoxib.