921630-22-0Relevant academic research and scientific papers
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
Chen, Austin,Bayly, Christopher,Bezen?on, Olivier,Richard-Bildstein, Sylvia,Dubé, Daniel,Dubé, Laurence,Gagné, Sébastien,Gallant, Michel,Gaudreault, Mireille,Grimm, Erich,Houle, Robert,Lacombe, Patrick,Laliberté, Sébastien,Lévesque, Jean-Fran?ois,Liu, Suzanna,MacDonald, Dwight,Mackay, Bruce,Martin, David,McKay, Dan,Powell, David,Remeň, L'ubo?,Soisson, Stephen,Toulmond, Sylvie
scheme or table, p. 2204 - 2209 (2010/06/19)
The discovery and SAR of a new series of substituted amino propanamide renin inhibitors are herein described. This work has led to the preparation of compounds with in vitro and in vivo profiles suitable for further development. Specifically, challenges p
Novel Piperidine Carboxylic Acid Amide Derivatives
-
Page/Page column 10, (2008/12/08)
The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these
RENIN INHIBITORS
-
Page/Page column 30, (2008/06/13)
The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency.
