92164-43-7

Basic information

• Product Name: 1H-Benzimidazole, 2-(5-nitro-2-methylphenyl)-
• CAS NO: 92164-43-7
• Molecular Formula: C14H11N3O2
• Molecular Weight: 253.26
• Mol File: 92164-43-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 2-(5-nitro-2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 2-(5-nitro-2-methylphenyl)-(92164-43-7)
• EPA Substance Registry System: 1H-Benzimidazole, 2-(5-nitro-2-methylphenyl)-(92164-43-7)

Safety Data

• Hazardous Substances Data: 92164-43-7(Hazardous Substances Data)

Upstream product

• 1975-52-6 5-nitro-o-toluic acid 
• 64688-68-2 2-methyl-5-nitrobenzoyl chloride 

Relevant articles and documents

Synthesis and evaluation of novel N-3-benzimidazolephenylbisamide derivatives for antiproliferative and Hedgehog pathway inhibitory activity

A series of novel N-3-benzimidazolephenylbisamide derivatives bearing the 4-benzyloxyphenyl moiety were synthesized and evaluated for their antiproliferative activity against MGC803, HT29, MKN45 and SW620 cancer cell lines in vitro. The pharmacological data demonstrated that the majority of the target compounds exhibited higher efficacy against MGC803, HT29 and MKN45 cells, among which compound 7m displayed higher antiproliferative activity than vismodegib. Furthermore, compound 7m manifested better inhibition of the Hedgehog (Hh) signaling pathway in different Hh-related assays and may compete with boron-dipyrromethene (BODIPY)-cyclopamine for binding to the human smoothened (Smo) receptor. In addition, molecular docking studies suggested that compound 7m interacts very closely with the vismodegib docking pose through hydrogen bonds at the taladegib binding site of the Smo receptor.