92173-66-5Relevant academic research and scientific papers
Copper-Catalyzed Inter/Intramolecular N-Alkenylation of Benzimidazoles via Tandem Processes Involving Selectively Mild Iodination of sp3 C-H Bond at α-Position of Ester
Lai, Ting-Ting,Xie, Dan,Zhou, Cheng-He,Cai, Gui-Xin
, p. 8806 - 8815 (2016/10/14)
Inter/intramolecular approaches to sp2 C-N bond formation of N-alkenyl benzimidazoles have been accomplished in the presence of an iodide anion associated with a copper catalyst. Both intermolecular and intramolecular reactions included tandem processes, in which selective iodination of sp3 C-H bond at the α-position of ester under mild conditions was demonstrated for the first time. Tandem reactions involving sp3 C-H activation via α-iodo ester intermediate under copper catalysis efficiently provided more than 20 novel azole compounds, and free radicals were not involved in this transformation.
CYANOACETYLENE AND ITS DERIVATIVES. VI. REACTION OF TERTIARY CYANOACETYLENE ALCOHOLS WITH BENZIMIDAZOLE
Skvortsov, Yu.M.,Mal'kina, A.G.,Trofimov, B.A.,Volkov, A.N.,Glazkova, N.P.,et al.
, p. 853 - 856 (2007/10/02)
The nucleophilic addition of benzimidazole to tertiary cyanoacetylene alcohols is regio- and stereospecific with the formation of Z-1-benzimidazoles.The use of alkali-metal hydroxides as catalysts leads to the formation of E-1-(2-cyanoethenyl)-benzimidazole as side product.
