92176-41-5Relevant academic research and scientific papers
IMIDAZOLE COMPOUND
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Paragraph 0227-0228; 0230, (2021/02/09)
PROBLEM TO BE SOLVED: To provide an imidazole compound which has: good solubility in raw materials when synthesizing a resin; and good reactivity in a dimerization-cleavage reaction in the resin. SOLUTION: The imidazole compound of the present invention i
PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4
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Page/Page column 54; 56; 71, (2020/05/21)
The present invention encompasses compounds of formula (I) wherein the groups R1,A, G, LK and t have the meanings given in the claims and specification, their use as degraders of SMARCA2 and/or SMARCA4, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Oligo-polycentric metalloporphyrin complex and preparation method of polycarbonate
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Paragraph 0149; 0150; 0151, (2018/12/02)
The invention provides an oligo-polycentric metalloporphyrin complex and a preparation method of polycarbonate. The oligo-polycentric metalloporphyrin complex has a structure shown in formula (1). With multiple active centers, the metalloporphyrin complex
Monolayer to Interdigitated Partial Bilayer Smectic C Transition in Thiophene-Based Spacer Mesogens: X-ray Diffraction and 13C Nuclear Magnetic Resonance Studies
Kesava Reddy,Varathan,Lobo, Nitin P.,Roy, Arun,Narasimhaswamy,Ramanathan
, p. 10831 - 10842 (2015/10/12)
Mesophase organization of molecules built with thiophene at the center and linked via flexible spacers to rigid side arm core units and terminal alkoxy chains has been investigated. Thirty homologues realized by varying the span of the spacers as well as the length of the terminal chains have been studied. In addition to the enantiotropic nematic phase observed for all the mesogens, the increase of the spacer as well as the terminal chain lengths resulted in the smectic C phase. The molecular organization in the smectic phase as investigated by temperature dependent X-ray diffraction measurements revealed an interesting behavior that depended on the length of the spacer vis-a-vis the length of the terminal chain. Thus, a tilted interdigitated partial bilayer organization was observed for molecules with a shorter spacer length, while a tilted monolayer arrangement was observed for those with a longer spacer length. High-resolution solid state 13C NMR studies carried out for representative mesogens indicated a U-shape for all the molecules, indicating that intermolecular interactions and molecular dynamics rather than molecular shape are responsible for the observed behavior. Models for the mesophase organization have been considered and the results understood in terms of segregation of incompatible parts of the mesogens combined with steric frustration leading to the observed lamellar order.
Nitrostyrene derivatives of adenosine 5'-glutarates modified with an alkyl spacer and their inhibitory activity on epidermal growth factor receptor protein tyrosine kinase
Peterli,Hubmann,Sequin,Mett,Traxler
, p. 59 - 69 (2007/10/02)
β-Nitrostyrene derivatives of adenosine 5'-glutarates are potent and selective bisubstrate-type inhibitors of the epidermal growth factor receptor protein tyrosine kinase (EGF-R PTK). In an attempt to improve the inhibitory activity, this type of compounds was modified with alkyl spacers of varying length between the nitrostyrene and the glutaryl units. The spacers consisted of 1, 3, 4, and 5 atoms to give compounds of the benzyl, oxyethyl, oxypropyl, and oxybutyl series, respectively (Schemes 1 and 2). Adenosine 5'-esters were prepared in the benzyl and oxypropyl series only. Compared to the compounds in the parent series without spacer (IC50 = 0.7-12 μM), most of the modified compounds inhibited the EGF-R PTK only marginally or were inactive (IC50 ≥ 100 μM). The only exceptions were the free acids 19 and 20 with IC50 values of ca. 5 μM. It is noteworthy that esterification of these two hydrogen glutarates with either MeOH or adenosine yielded inactive compounds, which is in contrast to the corresponding substances without spacers.
