92176-48-2Relevant academic research and scientific papers
Application of N-Tritylamio Acid 1-Benzotriazolyl Esters in Peptide Synthesis
Barlos, Kleomenis,Papaioannou, Dionysios,Sanida, Chariklia
, p. 1308 - 1318 (2007/10/02)
The application of N-tritylamino acid 1-benzotriazolyl esters 2 in peptide synthesis is investigated using as model compounds leucine-enkephalin (18) and leucine-enkephalinamide (19).The reactions are performed in solution and on the surface of solids.New spectrophotometric methods, based on the facile cleavage of the N-trityl group and on the measurement of the absorbance of the released triphenylmethanol, are used to monitor the coupling steps and to determine the free amino groups on the solid carrier.
