921760-46-5

Usage

Uses

Used in Pharmaceutical Industry:
6-Bromospiro[chroman-2,4'-piperidin]-4-one hydrochloride is used as an acetyl coenzyme A carboxylase (ACC) inhibitor for the development of pharmaceutical agents. ACC is a key enzyme involved in the regulation of fatty acid synthesis and energy metabolism. Inhibition of this enzyme can lead to the reduction of fatty acid synthesis, making it a potential target for the treatment of metabolic disorders and obesity.
In the synthesis of ACC inhibitors, 6-Bromospiro[chroman-2,4'-piperidin]-4-one hydrochloride serves as a valuable intermediate or building block. Its unique structure allows for the creation of novel compounds with improved potency, selectivity, and pharmacokinetic properties. By incorporating 6-BroMospiro[chroMan-2,4'-piperidin]-4-one hydrochloride into the design of new drugs, researchers can explore its potential in addressing unmet medical needs and developing more effective therapeutic options for patients.

Upstream product

• 1450-75-5 5-Bromo-2-hydroxyacetophenone 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 690632-38-3 tert-butyl 6-bromo-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate 

Downstream Products

• 690632-08-7 6-bromospiro[chroman-2,4'-piperidin]-4-one 

Relevant academic research and scientific papers

MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE

Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases. Formula (I):

INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME

The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as T

Substituted spirochromanone derivatives

The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of indole, 1H-indazole, 2H-indazole, 1H-thieno[2,3-c]pyrazole, 1H-pyrazolo[3,4-b]pyridine

N-sulfamoyl-N'-benzopyranpiperidine compounds and uses thereof

N-sulfamoyl-N′-benzopyranpiperidine compounds of formula I and their physiologically acceptable acid addition salts, pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment and/or inhibition of glaucoma, epilepsy, bipolar disorders, migraine, neuropathic pain, obesity, type II diabetes, metabolic syndrome, alcohol dependence, and/or cancer, and related concomitant and/or secondary diseases or conditions.

N-SULFAMOYL-N’-BENZOPYRANPIPERIDINES AS INHBITORS OF CARBONIC ANHYDRASES

The present invention relates to novel N-sulfamoyl-N'-benzopyranpiperidines of general formula (I) and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the prophylaxis and/or treatment and/or prevention and/or inhibition of glaucoma, epilepsy, bipolar disorders, migraine, neuropathic pain, obesity, type II diabetes, metabolic syndrome, alcohol dependence, and/or cancer, and its concomitant and/or secondary diseases or conditions.

SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS

The invention relates to a compound of a formula (I): , or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.