921763-73-7

Upstream product

• 179943-76-1 (1R,2R)-1-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-2-methyl-but-3-en-1-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 921763-72-6 (S)-2,2-diethyl-4-[(1R,2R)-1-(4-methoxy-benzyloxy)-2-methyl-but-3-enyl]-[1,3]dioxolane 

Downstream Products

• 921763-58-8 (2R,3R)-2-(4-methoxy-benzyloxy)-3-methyl-hex-5-ynal 
• 921763-74-8 (2S,3R,4R)-3-(4-methoxy-benzyloxy)-4-methyl-hept-6-yne-1,2-diol 
• 921763-57-7 (S)-2,2-diethyl-4-[(1R,2R)-1-(4-methoxybenzyloxy)-2-methylpent-4-ynyl]-[1,3]dioxolane 
• 921763-54-4 1-[(1R,2S,3R)-3-(dimethyl-phenyl-silanyl)-1-((R)-1-methyl-but-3-ynyl)-2-triethylsilanyloxypent-4-enyloxymethyl]-4-methoxy-benzene 
• 921763-59-9 (3R,4S,5R,6R)-3-(dimethylphenylsilanyl)-5-(4-methoxy-benzyloxy)-6-methyl-non-1-en-8-yl-4-ol 
• 921763-75-9 (1R,2R,3R)-1-{(2S,5S)-5-[(E)-4-((4R,5R)-2,2-dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-but-3-enyl]-tetrahydro-furan-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-hex-5-yn-1-ol 
• 921763-76-0 [(1R,2R,3R)-1-{(2S,5S)-5-[(E)-4-((4R,5R)-2,2-dimethyl-5-vinyl-[1,3]dioxolan-4-yl)-but-3-enyl]-tetrahydro-furan-2-yl}-2-(4-methoxy-benzyloxy)-3-methyl-hex-5-ynyloxy]-triethyl-silane 
• 921763-52-2 (4R,5R)-4-((E)-4-{(2S,4S,5R)-4-(dimethyl-phenyl-silanyl)-5-[(1S,2R,3R)-2-(4-methoxybenzyloxy)-3-methyl-1-triethylsilanyloxy-hex-5-ynyl]-tetrahydro-furan-2-yl}-but-1-enyl)-2,2-dimethyl-5-vinyl-[1,3]dioxolane 

Relevant academic research and scientific papers

Total synthesis of amphidinolide E

A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF3·Et2O promoted [3+2] annulation reaction between aldehyde 3 and allylsilan

Total synthesis of amphidinolide E and amphidinolide E stereoisomers

Four amphidinolide E stereoisomers, amphidinolide E (1), 2-epi-amphidinolide E (2), 19-epi-amphidinolide E (3), and 2-epi-19-epi-amphidinolide E (4), have been synthesized via the judicious union of aldehyde 5, allylsilanes 7 or 8, acids 9 or 10, and viny