921930-95-2

Usage

Physical form

White crystalline solid

Reactivity

Highly reactive

Versatility

Versatile building block

Functional groups

Bromine atom, two methoxy groups, nitrile functional group

Uses

Intermediate in the synthesis of various pharmaceuticals and organic compounds, production of antiviral and antibacterial agents, creation of new chemical entities for potential therapeutic use, intermediate in the synthesis of biologically active molecules, valuable component in organic synthesis and chemical research.

Upstream product

• 143-33-9 sodium cyanide 
• 773837-37-9 sodium cyanide 
• 34132-25-7 2-bromo-1-(bromomethyl)-3,5-dimethoxybenzene 
• 74726-76-4 2-bromo-3,5-dimethoxybenzyl alcohol 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 705-76-0 3,5-dimethoxybenzyl alcohol 

Downstream Products

• 1400655-49-3 (3,5-dimethoxyphenyl)(3,5,7-trimethoxyphenanthren-9-yl)methanone 
• 1400655-53-9 1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1-(3,5,7-trimethoxyphenanthren-9-yl)ethanol 
• 1400655-48-2 (E)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene 
• 1400655-58-4 (Z)-10-(1-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)vinyl)-2,4,6-trimethoxyphenanthrene 
• 1400655-54-0 5-(3,5-dimethoxyphenyl)-1,3,9-trimethoxy-4-(4-methoxyphenyl)acephenanthrylene 
• 1400655-57-3 3,5,7,11,13-pentamethoxy-9-(4-methoxybenzyl)-9H-indeno-[2,1-l]phenanthrene 
• 921930-98-5 5-(2-bromo-3,5-dimethoxy-benzyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxylic acid tert-butyl ester 
• 921930-97-4 (+/-)-5-(2-bromo-3,5-dimethoxybenzyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 921930-96-3 N-(2-(2-benzo[d][1,3]dioxol-5-yl)ethyl)-2-(bromo-3,5-dimethoxyphenyl)acetamide 

Relevant academic research and scientific papers

Total synthesis of laetevirenol A

The first complete synthesis of laetevirenol A was performed in nine steps via intramolecular Friedel-Crafts alkylation in a trans-selective manner. The key phenanthrene intermediate was synthesized by a one-pot Suzuki-Miyaura coupling and an aldol condensation cascade reaction.

Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.

Three new alkaloids (1-3) and twenty-one known compounds were isolated from the stem of Fissistigma oldhamii (Hemsl.) Merr. which was the ruler herb in an approved Traditional Chinese herbal formula used for treatment of rheumatoid arthritis in China and synthesis of one new immunosuppressive alkaloid was achieved. These compounds, including the crude extracts of this herb, exhibited strong activities in the inhibition of T and B cell proliferation.